Gene Review:
Sox2 - SRY (sex determining region Y)-box 2
Mus musculus
Synonyms:
Sox-2, Transcription factor SOX-2, lcc, ysb
Inada,
Tsukamoto,
Murakami,
Shenouda,
Tatematsu,
Walker,
Holmes,
Zhang,
Dickson,
Sandhu,
Kennedy,
Shen,
Sikorska,
Smith,
Ribecco-Lutkiewicz,
Tremblay,
Ambrosetti,
Marta Ramirez Gaite,
Mansukhani,
Zurakowski,
Robbert Rottier,
Basilico,
Ishida,
Carrier,
Cornivelli,
Bani-Yaghoub,
Lei,
Srivastava,
Mishra,
- Stem cells and gastric cancer: role of gastric and intestinal mixed intestinal metaplasia. Tatematsu, M., Tsukamoto, T., Inada, K. Cancer Sci. (2003)
- Isolation, characterization, and differential expression of the murine Sox-2 promoter. Wiebe, M.S., Wilder, P.J., Kelly, D., Rizzino, A. Gene (2000)
- Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Engelen, E., Akinci, U., Bryne, J.C., Hou, J., Gontan, C., Moen, M., Szumska, D., Kockx, C., van Ijcken, W., Dekkers, D.H., Demmers, J., Rijkers, E.J., Bhattacharya, S., Philipsen, S., Pevny, L.H., Grosveld, F.G., Rottier, R.J., Lenhard, B., Poot, R.A. Nat. Genet. (2011)
- SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Taranova, O.V., Magness, S.T., Fagan, B.M., Wu, Y., Surzenko, N., Hutton, S.R., Pevny, L.H. Genes Dev. (2006)
- Multipotent cell lineages in early mouse development depend on SOX2 function. Avilion, A.A., Nicolis, S.K., Pevny, L.H., Perez, L., Vivian, N., Lovell-Badge, R. Genes Dev. (2003)
- Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Reményi, A., Lins, K., Nissen, L.J., Reinbold, R., Schöler, H.R., Wilmanns, M. Genes Dev. (2003)
- Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Ashery-Padan, R., Marquardt, T., Zhou, X., Gruss, P. Genes Dev. (2000)
- New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Botquin, V., Hess, H., Fuhrmann, G., Anastassiadis, C., Gross, M.K., Vriend, G., Schöler, H.R. Genes Dev. (1998)
- Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Yuan, H., Corbi, N., Basilico, C., Dailey, L. Genes Dev. (1995)
- Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells. Catena, R., Tiveron, C., Ronchi, A., Porta, S., Ferri, A., Tatangelo, L., Cavallaro, M., Favaro, R., Ottolenghi, S., Reinbold, R., Schöler, H., Nicolis, S.K. J. Biol. Chem. (2004)
- Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. Maruyama, M., Ichisaka, T., Nakagawa, M., Yamanaka, S. J. Biol. Chem. (2005)
- Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Gontan, C., de Munck, A., Vermeij, M., Grosveld, F., Tibboel, D., Rottier, R. Dev. Biol. (2008)
- Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction. Kamachi, Y., Uchikawa, M., Collignon, J., Lovell-Badge, R., Kondoh, H. Development (1998)
- Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. Okumura-Nakanishi, S., Saito, M., Niwa, H., Ishikawa, F. J. Biol. Chem. (2005)
- Histone arginine methylation regulates pluripotency in the early mouse embryo. Torres-Padilla, M.E., Parfitt, D.E., Kouzarides, T., Zernicka-Goetz, M. Nature (2007)
- The Sox2 Regulatory Region 2 Functions as a Neural Stem Cell-specific Enhancer in the Telencephalon. Miyagi, S., Nishimoto, M., Saito, T., Ninomiya, M., Sawamoto, K., Okano, H., Muramatsu, M., Oguro, H., Iwama, A., Okuda, A. J. Biol. Chem. (2006)
- Role of Sox2 in the development of the mouse neocortex. Bani-Yaghoub, M., Tremblay, R.G., Lei, J.X., Zhang, D., Zurakowski, B., Sandhu, J.K., Smith, B., Ribecco-Lutkiewicz, M., Kennedy, J., Walker, P.R., Sikorska, M. Dev. Biol. (2006)
- Inhibition of DNA binding of Sox2 by the SUMO conjugation. Tsuruzoe, S., Ishihara, K., Uchimura, Y., Watanabe, S., Sekita, Y., Aoto, T., Saitoh, H., Yuasa, Y., Niwa, H., Kawasuji, M., Baba, H., Nakao, M. Biochem. Biophys. Res. Commun. (2006)
- The co-activator p300 associates physically with and can mediate the action of the distal enhancer of the FGF-4 gene. Nowling, T., Bernadt, C., Johnson, L., Desler, M., Rizzino, A. J. Biol. Chem. (2003)
- SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. Murakami, A., Shen, H., Ishida, S., Dickson, C. J. Biol. Chem. (2004)
- Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells. Johnson, L.R., Lamb, K.A., Gao, Q., Nowling, T.K., Rizzino, A. Mol. Reprod. Dev. (1998)
- Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. Mansukhani, A., Ambrosetti, D., Holmes, G., Cornivelli, L., Basilico, C. J. Cell Biol. (2005)
- Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Que, J., Okubo, T., Goldenring, J.R., Nam, K.T., Kurotani, R., Morrisey, E.E., Taranova, O., Pevny, L.H., Hogan, B.L. Development (2007)
- Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages. Wood, H.B., Episkopou, V. Mech. Dev. (1999)
- GABPalpha regulates Oct-3/4 expression in mouse embryonic stem cells. Kinoshita, K., Ura, H., Akagi, T., Usuda, M., Koide, H., Yokota, T. Biochem. Biophys. Res. Commun. (2007)
- Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. Gontan, C., Güttler, T., Engelen, E., Demmers, J., Fornerod, M., Grosveld, F.G., Tibboel, D., Görlich, D., Poot, R.A., Rottier, R.J. J. Cell. Biol. (2009)
- Transplanted embryonic stem cells successfully survive, proliferate, and migrate to damaged regions of the mouse brain. Srivastava, A.S., Shenouda, S., Mishra, R., Carrier, E. Stem Cells (2006)
- Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. D'Amour, K.A., Gage, F.H. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas. Wilson, M.E., Yang, K.Y., Kalousova, A., Lau, J., Kosaka, Y., Lynn, F.C., Wang, J., Mrejen, C., Episkopou, V., Clevers, H.C., German, M.S. Diabetes (2005)
- Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea. Doetzlhofer, A., White, P., Lee, Y.S., Groves, A., Segil, N. Brain Res. (2006)