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Gene Review

NPVF  -  neuropeptide VF precursor

Gallus gallus

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High impact information on NPVF

  • The origin of the peptide precursor (PRH) has been unclear, and the only feature resembling other known human neuropeptide sequences is the C-terminal RF-motif, also present in the neuropeptide FF and the neuropeptide RF amide-related peptide families (RFRP) [1].
  • These results indicated that avian RFRP, unlike the mammalian one, directly acts on the pituitary gland via receptors to regulate gonadotropin release [2].


  1. The ancestry of the prolactin-releasing hormone precursor. Lagerström, M.C., Fredriksson, R., Bjarnadottir, T.K., Schiöth, H.B. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  2. Chicken RFamide-related peptide (GnIH) and two distinct receptor subtypes: identification, molecular characterization, and evolutionary considerations. Ikemoto, T., Park, M.K. J. Reprod. Dev. (2005) [Pubmed]
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