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Gene Review:

tcaA - bicyclomycin and teicoplanin resistance...

Staphylococcus aureus RF122

Maki, H. et al., Wootton, M. et al.

Wootton, Macgowan, Walsh,

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Disease relevance of tcaA

tcaA inactivation increases glycopeptide resistance in Staphylococcus aureus [1].

High impact information on tcaA

Complementation of these two GISA strains with a functional tcaA allele reduced their levels of teicoplanin and vancomycin resistance five- to eightfold and twofold, respectively [1].
Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains [2].

Associations of tcaA with chemical compounds

The data presented here indicate that inactivation of tcaA contributes to and plays a relevant role in glycopeptide resistance in S. aureus clinical isolates [1].

Analytical, diagnostic and therapeutic context of tcaA

Northern blot analysis of the tcaRAB region showed that the tcaA gene is expressed only weakly over the growth cycle and is strongly inducible by teicoplanin [1].

References

tcaA inactivation increases glycopeptide resistance in Staphylococcus aureus. Maki, H., McCallum, N., Bischoff, M., Wada, A., Berger-Bächi, B. Antimicrob. Agents Chemother. (2004) [Pubmed]
Expression of tcaA and mprF and glycopeptide resistance in clinical glycopeptide-intermediate Staphylococcus aureus (GISA) and heteroGISA strains. Wootton, M., Macgowan, A.P., Walsh, T.R. Biochim. Biophys. Acta (2005) [Pubmed]

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