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Gene Review:

glmM - phosphoglucosamine mutase

Staphylococcus aureus RF122

Cordwell, S.J. et al., Komatsuzawa, H. et al., Glanzmann, P. et al.

Cordwell, Larsen, Cole, Walsh, Komatsuzawa, Ohta, Sugai, Fujiwara, Glanzmann, Berger-BächiB, Suginaka,

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Disease relevance of SAB2041c

The Staphylococcus aureus phosphoglucosamine mutase gene glmM was shown to be the last gene of a three-cistron operon, orf1-orf2-glmM [1].

High impact information on SAB2041c

The fmtB gene was mapped downstream of the phosphoglucosamine mutase operon glmM which catalyses formation of glucosamine-1-phosphate [2].
Upon growth of both strains in the presence of TX-100, no effects on the production of the essential methicillin-resistance factor FemA were detected, whereas phosphoglucosamine mutase (GlmM) production was reduced in COL alone [3].

References

glmM operon and methicillin-resistant glmM suppressor mutants in Staphylococcus aureus. Glanzmann, P., Gustafson, J., Komatsuzawa, H., Ohta, K., Berger-Bächi, B. Antimicrob. Agents Chemother. (1999) [Pubmed]
Tn551-mediated insertional inactivation of the fmtB gene encoding a cell wall-associated protein abolishes methicillin resistance in Staphylococcus aureus. Komatsuzawa, H., Ohta, K., Sugai, M., Fujiwara, T., Glanzmann, P., Berger-BächiB, n.u.l.l., Suginaka, H. J. Antimicrob. Chemother. (2000) [Pubmed]
Comparative proteomics of Staphylococcus aureus and the response of methicillin-resistant and methicillin-sensitive strains to Triton X-100. Cordwell, S.J., Larsen, M.R., Cole, R.T., Walsh, B.J. Microbiology (Reading, Engl.) (2002) [Pubmed]

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