Disease relevance of hysA2

• The hyaluronate lyase of Staphylococcus aureus - a virulence factor [1]?
• Cloning and sequencing of the hyaluronate lyase gene from Propionibacterium acnes [2].
• The Staphylococcus aureus 8325-4 hyaluronate lyase gene (hysA) was identified after detecting hyaluronate lyase activity expressed by phages from a genomic library [3].

High impact information on hysA2

• The importance of HL for pathogenicity was assessed by comparing the virulence of the HL(-) mutant strain to that of the w.t. in an established mouse abscess model of S. aureus infection [1].
• HysA shares 35 and 36% amino acid sequence identity with group B streptococcal hyaluronate lyase and pneumococcal hyaluronidase, respectively [3].
• Cloning, nucleotide sequence determination and expression of the Staphylococcus aureus hyaluronate lyase gene [3].
• The biomass and the amounts of toxic shock syndrome toxin 1, acid phosphatase, proteinase, hyaluronate lyase, and total exoprotein were estimated at each condition [4].

Biological context of hysA2

• These results strongly suggest that HL is a virulence factor which is important in the early stages of subcutaneous infections [1].

References