Disease relevance of asp23

• Transcriptional analysis of sarA and the sigma(B)-dependent gene asp23 revealed the functions of RsbU and RsbV as positive regulators and of RsbW as a negative regulator of sigma(B) activity, indicating regulation of sigma(B) activity similar to that characterized for Bacillus subtilis and Staphylococcus aureus [1].
• Regulation of sigmaB-dependent transcription of sigB and asp23 in two different Staphylococcus aureus strains [2].

High impact information on asp23

• Growth curve analyses revealed longer doubling times and lower final densities for SCVs than for normal strains. sigB activity was measured by transcription analysis of the sigB target gene asp23 [3].
• For nearly all SCVs, expression of all regulators was decreased as assessed by asp23 reverse transcription-PCR for sigB and Northern analysis for sarA and agr [3].
• However, almost no induction of asp23 expression was found after heat or ethanol stress in S. aureus MA13 grown in a synthetic medium, where the basal expression level of asp23 is high [2].
• RNAIII, rot and sarR genes, for the regulatory factors, and asp23 and cflA genes, for the virulence factors, were strongly expressed, whatever the oxygenation and the strains [4].

Chemical compound and disease context of asp23

• In Bacillus subtilis, the asp23 promoter from S. aureus is regulated like other sigmaB-dependent promoters, which are strongly induced by heat and ethanol stress [2].

Other interactions of asp23

• SAL induced sarA P3 and asp23 promoter activities in a dose-dependent manner in the parental strain [5].

References