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Gene Review:

tonB - energy transducer; uptake of iron,...

Shigella dysenteriae Sd197

Reeves, S.A. et al., Mills, M. et al.

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Disease relevance of tonB

Analysis of the shuA DNA sequence indicates that this gene encodes a protein with homology to TonB-dependent receptors of gram-negative bacteria [1].
To assess the importance of TonB-dependent iron transport systems to growth of Shigella in vivo, a tonB mutant of Shigella dysenteriae was isolated and tested in cultured cells [2].

High impact information on tonB

The tonB mutant invaded epithelial cells, but did not form plaques in confluent monolayers of Henle cells, indicating an inability of this mutant to spread from cell to cell [2].

References

Identification of shuA, the gene encoding the heme receptor of Shigella dysenteriae, and analysis of invasion and intracellular multiplication of a shuA mutant. Mills, M., Payne, S.M. Infect. Immun. (1997) [Pubmed]
TonB is required for intracellular growth and virulence of Shigella dysenteriae. Reeves, S.A., Torres, A.G., Payne, S.M. Infect. Immun. (2000) [Pubmed]

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