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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KIF5C  -  kinesin family member 5C

Homo sapiens

Synonyms: CDCBM2, KIAA0531, KINN, Kinesin heavy chain isoform 5C, Kinesin heavy chain neuron-specific 2, ...
 
 
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High impact information on KIF5C

  • The GRIF-1 binding site of KIF5C was mapped using truncation constructs in yeast two-hybrid interaction assays, co-immunoprecipitations, and co-localization studies following expression in mammalian cells [1].
  • The C-terminal domains of KIF5B and KIF5C, but not KIF5A, associate directly with importin-beta in a RanGTPase-dependent fashion in vivo and in vitro, indicating importin-beta is an endogenous cargo for a subset of KIF5s in retinal neurons [2].
 

Other interactions of KIF5C

  • Refined studies using yeast two-hybrid interactions and co-immunoprecipitations showed that GRIF-1 and GRIF-1-(124-283) associated with the cargo binding region within the KIF5C non-motor domain [1].

References

  1. Mapping the GRIF-1 Binding Domain of the Kinesin, KIF5C, Substantiates a Role for GRIF-1 as an Adaptor Protein in the Anterograde Trafficking of Cargoes. Smith, M.J., Pozo, K., Brickley, K., Stephenson, F.A. J. Biol. Chem. (2006) [Pubmed]
  2. Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization. Mavlyutov, T.A., Cai, Y., Ferreira, P.A. Traffic (2002) [Pubmed]
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