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Gene Review

TRAK2  -  trafficking protein, kinesin binding 2

Homo sapiens

Synonyms: ALS2CR3, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein, CALS-C, GRIF-1, GRIF1, ...
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High impact information on TRAK2


Anatomical context of TRAK2

  • These findings support a role for GRIF-1 as a kinesin adaptor molecule requisite for the anterograde delivery of defined cargoes such as mitochondria and/or vesicles incorporating beta2 subunit-containing GABA(A) receptors, in the brain [2].
  • Like Hrs, both overexpression and siRNA-mediated depletion of GRIF1 inhibit the degradation of internalized epidermal growth factor receptors and block the trafficking of the receptors from early endosomes to the lysosomal pathway [3].
  • GRIF-1 [GABA(A) (gamma-aminobutyric acid(A)) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses [4].

Associations of TRAK2 with chemical compounds


Physical interactions of TRAK2


Other interactions of TRAK2

  • Refined studies using yeast two-hybrid interactions and co-immunoprecipitations showed that GRIF-1 and GRIF-1-(124-283) associated with the cargo binding region within the KIF5C non-motor domain [2].

Analytical, diagnostic and therapeutic context of TRAK2


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