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Gene Review

bab1  -  bric a brac 1

Drosophila melanogaster

Synonyms: BAB, BAB1, Bab1, CG13910, CG9097, ...
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High impact information on bab1

  • In this paper, we show that the BTB domain of bab can mediate protein dimerization in vitro [1].
  • The gene bric à brac (bab) is required for the proper development of the limbs and ovary in Drosophila melanogaster. bab encodes a BTB domain (also called a POZ domain), an approximately 115-amino-acid conserved motif found primarily in the N termini of zinc finger proteins [1].
  • It consists of two structurally and functionally related genes, bab1 and bab2, each of which encodes a single nuclear protein [2].
  • The Drosophila BTB/POZ (Bric-a-brac Tramtrack Broad complex/Pox virus and Zinc finger) domain-containing Tramtrack (Ttk) proteins have been previously shown to be transcriptional repressors and inhibitors of the neuronal fate of cells such as photoreceptors [3].

Biological context of bab1

  • In addition, we demonstrate that the first 51 amino acids of the bab BTB domain are sufficient for dimerization, and we identify amino acids within this region that are required for binding [1].


  1. The BTB domain of bric à brac mediates dimerization in vitro. Chen, W., Zollman, S., Couderc, J.L., Laski, F.A. Mol. Cell. Biol. (1995) [Pubmed]
  2. The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila. Couderc, J.L., Godt, D., Zollman, S., Chen, J., Li, M., Tiong, S., Cramton, S.E., Sahut-Barnola, I., Laski, F.A. Development (2002) [Pubmed]
  3. Tramtrack69 is positively and autonomously required for Drosophila photoreceptor development. Lai, Z.C., Li, Y. Genetics (1999) [Pubmed]
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