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Gene Review:

bab1 - bric a brac 1

Drosophila melanogaster

Synonyms: BAB, BAB1, Bab1, CG13910, CG9097, ...

Chen, W. et al., Lai, Z.C. et al., Couderc, J.L. et al.

Lai, Li, Couderc, Godt, Zollman, Chen, Li, Tiong, Cramton, Sahut-Barnola, Laski,

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High impact information on bab1

In this paper, we show that the BTB domain of bab can mediate protein dimerization in vitro [1].
The gene bric à brac (bab) is required for the proper development of the limbs and ovary in Drosophila melanogaster. bab encodes a BTB domain (also called a POZ domain), an approximately 115-amino-acid conserved motif found primarily in the N termini of zinc finger proteins [1].
It consists of two structurally and functionally related genes, bab1 and bab2, each of which encodes a single nuclear protein [2].
The Drosophila BTB/POZ (Bric-a-brac Tramtrack Broad complex/Pox virus and Zinc finger) domain-containing Tramtrack (Ttk) proteins have been previously shown to be transcriptional repressors and inhibitors of the neuronal fate of cells such as photoreceptors [3].

Biological context of bab1

In addition, we demonstrate that the first 51 amino acids of the bab BTB domain are sufficient for dimerization, and we identify amino acids within this region that are required for binding [1].

References

The BTB domain of bric à brac mediates dimerization in vitro. Chen, W., Zollman, S., Couderc, J.L., Laski, F.A. Mol. Cell. Biol. (1995) [Pubmed]
The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila. Couderc, J.L., Godt, D., Zollman, S., Chen, J., Li, M., Tiong, S., Cramton, S.E., Sahut-Barnola, I., Laski, F.A. Development (2002) [Pubmed]
Tramtrack69 is positively and autonomously required for Drosophila photoreceptor development. Lai, Z.C., Li, Y. Genetics (1999) [Pubmed]

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