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Gene Review

bab2  -  bric a brac 2

Drosophila melanogaster

Synonyms: BAB, BAB2, BTB-II, Bab2, BtbII, ...
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Disease relevance of bab2


High impact information on bab2

  • For example, bric-a-brac2 is normally expressed in the central part of the tarsus domain but expands into distal and proximal regions in bowl clones [2].
  • It consists of two structurally and functionally related genes, bab1 and bab2, each of which encodes a single nuclear protein [3].
  • We show that the BTB/POZ domains of BAB1 and BAB2 are sufficient to mediate a direct interaction with BIP2/dTAF(II)155 [4].
  • Multiple bab alleles that confer distinct phenotypes appear to segregate in natural populations at appreciable frequencies, suggesting that intraspecific and interspecific variation in abdominal pigmentation may share a similar genetic basis [5].
  • NAC1 is a member of the Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger family of transcription factors and has been shown by overexpression studies to prevent the development of behavioral sensitization resulting from repeated cocaine treatment [6].

Biological context of bab2


  1. The Drosophila melanogaster BTB proteins bric à brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif. Lours, C., Bardot, O., Godt, D., Laski, F.A., Couderc, J.L. Nucleic Acids Res. (2003) [Pubmed]
  2. Bowl is required downstream of Notch for elaboration of distal limb patterning. de Celis Ibeas, J.M., Bray, S.J. Development (2003) [Pubmed]
  3. The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila. Couderc, J.L., Godt, D., Zollman, S., Chen, J., Li, M., Tiong, S., Cramton, S.E., Sahut-Barnola, I., Laski, F.A. Development (2002) [Pubmed]
  4. The BTB/POZ domain of the regulatory proteins Bric à brac 1 (BAB1) and Bric à brac 2 (BAB2) interacts with the novel Drosophila TAF(II) factor BIP2/dTAF(II)155. Pointud, J.C., Larsson, J., Dastugue, B., Couderc, J.L. Dev. Biol. (2001) [Pubmed]
  5. Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogaster. Kopp, A., Graze, R.M., Xu, S., Carroll, S.B., Nuzhdin, S.V. Genetics (2003) [Pubmed]
  6. The mouse nac1 gene, encoding a cocaine-regulated Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger protein, is regulated by AP1. Mackler, S.A., Homan, Y.X., Korutla, L., Conti, A.C., Blendy, J.A. Neuroscience (2003) [Pubmed]
  7. Caste- and development-associated gene expression in a lower termite. Scharf, M.E., Wu-Scharf, D., Pittendrigh, B.R., Bennett, G.W. Genome Biol. (2003) [Pubmed]
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