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Gene Review:

traE - conjugal transfer pilus assembly protein TraE

Escherichia coli

Li, Z. et al., Achtman, M. et al.

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Disease relevance of traE

In addition, similar to E. coli Topo III, the TraE protein is a potent decatenase and can substitute for Topo III activity in vivo [1].

High impact information on traE

We have now assigned the tra proteins to cytoplasm (TraIp and 2b), inner membrane (TraEp, TraMp, and TraSp), and outer membrane (6e, TraAp, TraBp, TraJp, TraKp, TraLp, and TraTp). two proteins, TraDp and 6d, were associated with both inner and outer membranes [2].
The biochemical properties of the TraE protein in vitro suggest that the protein may be involved in the resolution of plasmid DNA replication intermediates either during vegetative replication or in conjugative DNA transfer [1].

References

The traE gene of plasmid RP4 encodes a homologue of Escherichia coli DNA topoisomerase III. Li, Z., Hiasa, H., Kumar, U., DiGate, R.J. J. Biol. Chem. (1997) [Pubmed]
Export without proteolytic processing of inner and outer membrane proteins encoded by F sex factor tra cistrons in Escherichia coli minicells. Achtman, M., Manning, P.A., Edelbluth, C., Herrlich, P. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]

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