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Gene Review

Nova2  -  neuro-oncological ventral antigen 2

Mus musculus

Synonyms: Gm1424, LOC384569
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High impact information on Nova2

  • We used a stringent algorithm to identify 591 exons that were differentially spliced in the brain relative to immune tissues, and 6.6% of these showed major splicing defects in the neocortex of Nova2-/- mice [1].
  • In the postnatal mouse brain, Nova-2 is expressed in a pattern that is largely reciprocal with Nova-1, including high levels of Nova-2 expression in the neocortex and hippocampus [2].


  1. Nova regulates brain-specific splicing to shape the synapse. Ule, J., Ule, A., Spencer, J., Williams, A., Hu, J.S., Cline, M., Wang, H., Clark, T., Fraser, C., Ruggiu, M., Zeeberg, B.R., Kane, D., Weinstein, J.N., Blume, J., Darnell, R.B. Nat. Genet. (2005) [Pubmed]
  2. The neuronal RNA-binding protein Nova-2 is implicated as the autoantigen targeted in POMA patients with dementia. Yang, Y.Y., Yin, G.L., Darnell, R.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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