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Gene Review:

exex - extra-extra

Drosophila melanogaster

Synonyms: CG8254, DHB9, Dmel\CG8254, HB9, Hb9, ...

Odden, J.P. et al.

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High impact information on exex

Drosophila HB9 is expressed in a subset of motoneurons and interneurons, where it regulates gene expression and axon pathfinding [1].
Conversely, ectopic HB9 expression causes an expansion of ventral motoneuron projections and repression of Even-skipped [1].

Biological context of exex

RNA interference knockdown of HB9 levels leads to defects in motoneuron ventral muscle target recognition, ectopic expression of a marker for dorsally projecting motoneurons (Even-skipped), and defects in serotonergic interneuronal projections [1].

References

Drosophila HB9 is expressed in a subset of motoneurons and interneurons, where it regulates gene expression and axon pathfinding. Odden, J.P., Holbrook, S., Doe, C.Q. J. Neurosci. (2002) [Pubmed]

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