High impact information on simj

• Interestingly, the simjang gene encodes a protein that is a component of the chromatin remodeling complex recruited by methyl-CpG-DNA binding proteins, suggesting that epigenetic information is crucial for specifying cardiac precursors [1].
• With the exception of the developing salivary glands which express high levels of p66, developing tissues express the p55 form of Dsrc28C [2].
• The Dsrc28C gene encodes two major proteins, p66 and p55, each of which contains a tyrosine kinase domain [2].
• Although heterozygosity for p66 enhances a wingless phenotype in the eye, loss-of-function clones in the wing and the eye discs do not have any detectable phenotype, possibly due to redundancy with the Sin3 complex [3].

Biological context of simj

• Overexpression of p66, on the other hand, can repress wingless-dependent phenotypes [3].

Analytical, diagnostic and therapeutic context of simj

• By co-immunoprecipitation, p66 associates with dMi-2, a known NURD complex member [3].

References