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Gene Review

Btk29A  -  Btk family kinase at 29A

Drosophila melanogaster

Synonyms: C-src2, C-src4, CG18355, CG8049, CT2415, ...
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High impact information on Btk29A

  • Drosophila ring canal growth requires Src and Tec kinases [1].
  • The 66-kD protein was shown to represent the cell periphery-associated form of the protein through antibody staining of larval salivary glands expressing a heat shock promoter-driven, full-length Dsrc28C cDNA [2].
  • Indirect immunofluorescence microscopy reveals that Dsrc28C protein is localized to the cell periphery during cellular blastoderm and gastrulation [2].
  • Tec29 encodes the only known Drosophila member of the Tec tyrosine kinases [3].
  • Loss of Tec29 function in the female germline results in a phenotype strikingly similar to that caused by the loss of Src64 function [4].

Biological context of Btk29A


Anatomical context of Btk29A

  • Tec29 mutant egg chambers are defective in transfer of cytoplasm from the accessory nurse cells through the ring canals into the oocyte [3].
  • Tec29 controls actin remodeling and endoreplication during invagination of the Drosophila embryonic salivary glands [8].

Associations of Btk29A with chemical compounds

  • The Drosophila Btk29A tyrosine kinase is suggested to be involved in diverse processes, although its target proteins are unknown [6].
  • Tec29 activity is required for its own ring canal localization, suggesting that a phosphotyrosine ligand for the SH2 domain is generated by Tec29 itself [7].
  • Novel structural features of the Dsrc28C protein include a basic pI and a polyglycine domain near the amino terminus [9].

Enzymatic interactions of Btk29A

  • Src64 regulates this process by phosphorylating Y677 within the kinase domain of Tec29, an event required for Tec29 activation [7].

Regulatory relationships of Btk29A

  • In addition, we show that a mutation in Tec29A partially suppresses a gain-of-function mutation in tor [10].

Other interactions of Btk29A


  1. Drosophila ring canal growth requires Src and Tec kinases. Cooley, L. Cell (1998) [Pubmed]
  2. Embryonic expression of a Drosophila src gene: alternate forms of the protein are expressed in segmental stripes and in the nervous system. Vincent, W.S., Gregory, R.J., Wadsworth, S.C. Genes Dev. (1989) [Pubmed]
  3. The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development. Roulier, E.M., Panzer, S., Beckendorf, S.K. Mol. Cell (1998) [Pubmed]
  4. SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth. Guarnieri, D.J., Dodson, G.S., Simon, M.A. Mol. Cell (1998) [Pubmed]
  5. Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster. Beckett, K., Baylies, M.K. Dev. Biol. (2006) [Pubmed]
  6. Enhanced phosphorylation and enzymatic activity of phosphoglucomutase by the Btk29A tyrosine kinase in Drosophila. Inoue, H., Kondo, S., Hinohara, Y., Juni, N., Yamamoto, D. Arch. Biochem. Biophys. (2003) [Pubmed]
  7. Localization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms. Lu, N., Guarnieri, D.J., Simon, M.A. EMBO J. (2004) [Pubmed]
  8. Tec29 controls actin remodeling and endoreplication during invagination of the Drosophila embryonic salivary glands. Chandrasekaran, V., Beckendorf, S.K. Development (2005) [Pubmed]
  9. Primary sequence and developmental expression of a novel Drosophila melanogaster src gene. Gregory, R.J., Kammermeyer, K.L., Vincent, W.S., Wadsworth, S.G. Mol. Cell. Biol. (1987) [Pubmed]
  10. Identification of autosomal regions involved in Drosophila Raf function. Li, W., Noll, E., Perrimon, N. Genetics (2000) [Pubmed]
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