Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Atg1 - Autophagy-specific gene 1

Drosophila melanogaster

Synonyms: ATG1, CG10967, DK-4, DmATG1, Dmel\CG10967, ...

Scott, R.C. et al., Lee, S.B. et al.

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High impact information on Atg1

Here, we circumvent this difficulty by directly manipulating autophagy rates in Drosophila through the autophagy-specific protein kinase Atg1 [1].

Regulatory relationships of Atg1

We demonstrated that ATG1 specifically inhibits S6K activity by blocking phosphorylation of S6K at Thr 389 [2].

References

Direct induction of autophagy by atg1 inhibits cell growth and induces apoptotic cell death. Scott, R.C., Juh??sz, G., Neufeld, T.P. Curr. Biol. (2007) [Pubmed]
ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase. Lee, S.B., Kim, S., Lee, J., Park, J., Lee, G., Kim, Y., Kim, J.M., Chung, J. EMBO Rep. (2007) [Pubmed]

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