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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

VSX1  -  visual system homeobox 1

Gallus gallus

 
 
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Disease relevance of VSX1

  • No significant changes were observed in the number of other retinal neurons, including those that express RA4 (ganglion cells), pax6 (ganglion cells and amacrine cells), and chx10 (bipolar cells) [1].
 

High impact information on VSX1

  • In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax6 and Chx10, transcription factors expressed by embryonic retinal progenitors [2].
  • Chx10 and Chx10-1 are expressed in the early retinal neuroepithelium, but not in the pigment epithelium and lens [3].

References

  1. neuroD induces photoreceptor cell overproduction in vivo and de novo generation in vitro. Yan, R.T., Wang, S.Z. J. Neurobiol. (1998) [Pubmed]
  2. Müller glia are a potential source of neural regeneration in the postnatal chicken retina. Fischer, A.J., Reh, T.A. Nat. Neurosci. (2001) [Pubmed]
  3. Expression of Chx10 and Chx10-1 in the developing chicken retina. Chen, C.M., Cepko, C.L. Mech. Dev. (2000) [Pubmed]
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