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Gene Review

PHOX2B  -  paired-like homeobox 2b

Gallus gallus

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Disease relevance of PHOX2B

  • The expression of Mash1 (Cash1), Phox2b and Phox2a in the chick ciliary ganglion is followed by the sequential expression of panneuronal, noradrenergic and cholinergic marker genes [1].

High impact information on PHOX2B

  • We further show that both the PH and P/M sites are essential for Hox-Pbx-Prep ternary complex formation and regulation of the Phox2b enhancer activity in ventral r4 [2].
  • In contrast, Phox2b coordinates generic and noradrenergic gene expression, recruiting Mash1/Cash1, which may have a major function in the control of pan-neuronal gene expression during noradrenergic neuron development [3].
  • Here, we demonstrate that the Phox2b-induced generation of ectopic noradrenergic neurons in chick peripheral nerve involves the induction of Cash1, the chick homolog of Mash1 [3].


  1. Molecular control of ciliary neuron development: BMPs and downstream transcriptional control in the parasympathetic lineage. Müller, F., Rohrer, H. Development (2002) [Pubmed]
  2. Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins. Samad, O.A., Geisen, M.J., Caronia, G., Varlet, I., Zappavigna, V., Ericson, J., Goridis, C., Rijli, F.M. Development (2004) [Pubmed]
  3. Interaction of Mash1 and Phox2b in sympathetic neuron development. Stanke, M., Stubbusch, J., Rohrer, H. Mol. Cell. Neurosci. (2004) [Pubmed]
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