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Gene Review

FGFR1IIIC  -  FGF receptor

Sus scrofa

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High impact information on FGFR1IIIC

  • We show that the ectodomains of FGFR1 IIIc and FGFR2 IIIc exhibit specific interactions with different characteristics for both heparin and porcine mucosal HS [1].
  • We also proposed that heparin would exert a similar action to FGF, because this proteoglycan not only binds to the FGF receptor, but also facilitates the release of FGF from the cardiac extracellular matrix and promotes its binding to a high-affinity receptor [2].
  • The dual mechanism, i.e., stimulation of HIF-1alpha and FGF receptor expression, likely accounts for the functional benefits of PR39 [3].
  • In order to localize a rich source of basic FGF receptor, we examined the distribution of basic FGF binding sites in brain, stomach, lung, spleen, kidney, liver and intestine membrane preparations from adult guinea pig [4].


  1. Fibroblast growth factor receptors 1 and 2 interact differently with heparin/heparan sulfate. Implications for dynamic assembly of a ternary signaling complex. Powell, A.K., Fernig, D.G., Turnbull, J.E. J. Biol. Chem. (2002) [Pubmed]
  2. Basic fibroblast growth factor and heparin influence coronary arteriolar tone by causing endothelium-dependent dilation. Tiefenbacher, C.P., Chilian, W.M. Cardiovasc. Res. (1997) [Pubmed]
  3. Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation. Post, M.J., Sato, K., Murakami, M., Bao, J., Tirziu, D., Pearlman, J.D., Simons, M. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  4. Distribution of basic fibroblast growth factor binding sites in various tissue membrane preparations from adult guinea pig. Ledoux, D., Méreau, A., Dauchel, M.C., Barritault, D., Courty, J. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
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