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MeSH Review

Extracellular Matrix

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Disease relevance of Extracellular Matrix


High impact information on Extracellular Matrix


Chemical compound and disease context of Extracellular Matrix


Biological context of Extracellular Matrix


Anatomical context of Extracellular Matrix


Associations of Extracellular Matrix with chemical compounds

  • Extracellular matrices are made up of different combinations of collagens, elastin, hyaluronic acid, proteoglycans and various glycoproteins such as fibronectin [26].
  • We propose that pp41/43FRNK functions as an endogenous regulator of pp125FAK, thus providing an unusual means to regulate both tyrosine kinase activity and cellular adhesion to the extracellular matrix [21].
  • Thus, heparin inhibits the production of four proteinases (tissue plasminogen activator, collagenase, stromelysin and 92-kD gelatinase) that form an interdependent system capable of degrading all the major components of the extracellular matrix [27].
  • We propose that an extracellular matrix containing Pio and Dp provides a structural network in the luminal space, around which cell rearrangements can take place in an ordered fashion without losing interconnections [28].
  • Each domain consists of two antiparallel beta sheets and is folded topologically identically to single fibronectin type III domains from the extracellular matrix proteins tenascin and fibronectin. beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains [29].

Gene context of Extracellular Matrix

  • The position-specific (PS) integrins of Drosophila are highly homologous to vertebrate integrins, most of which are cell-surface receptors for extracellular matrix components [30].
  • A green fluorescent protein (GFP)-NompA fusion protein is localized to the dendritic cap, an extracellular matrix that covers the ciliary outer segment of the sensory process and that shows organizational defects in nompA mutants [31].
  • Solid-phase binding assays indicated a preferential affinity of native SPARC for several proteins comprising the extracellular matrix, including types III and V collagen, and thrombospondin [32].
  • This novel "deadhesive" activity of PAI-1 toward a variety of cells growing on different extracellular matrices may begin to explain why high PAI-1 levels often are associated with a poor prognosis in human metastatic disease [33].
  • This occurs by either redistribution from other extracellular matrices or unmasking of nidogen 2 epitopes, as its production does not appear to be upregulated [34].

Analytical, diagnostic and therapeutic context of Extracellular Matrix


  1. Transforming growth factor-beta 1 is decreased in remodeling hypertensive bovine pulmonary arteries. Botney, M.D., Parks, W.C., Crouch, E.C., Stenmark, K., Mecham, R.P. J. Clin. Invest. (1992) [Pubmed]
  2. The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. Bergelson, J.M., Chan, B.M., Finberg, R.W., Hemler, M.E. J. Clin. Invest. (1993) [Pubmed]
  3. Transforming growth factor-beta activity in sheep lung lymph during the development of pulmonary hypertension. Perkett, E.A., Lyons, R.M., Moses, H.L., Brigham, K.L., Meyrick, B. J. Clin. Invest. (1990) [Pubmed]
  4. Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices. Tomaselli, K.J., Reichardt, L.F., Bixby, J.L. J. Cell Biol. (1986) [Pubmed]
  5. Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia. Nabel, E.G., Shum, L., Pompili, V.J., Yang, Z.Y., San, H., Shu, H.B., Liptay, S., Gold, L., Gordon, D., Derynck, R. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy. Stone, E.M., Lotery, A.J., Munier, F.L., Héon, E., Piguet, B., Guymer, R.H., Vandenburgh, K., Cousin, P., Nishimura, D., Swiderski, R.E., Silvestri, G., Mackey, D.A., Hageman, G.S., Bird, A.C., Sheffield, V.C., Schorderet, D.F. Nat. Genet. (1999) [Pubmed]
  7. An unusual mosaic protein with a protease domain, encoded by the nudel gene, is involved in defining embryonic dorsoventral polarity in Drosophila. Hong, C.C., Hashimoto, C. Cell (1995) [Pubmed]
  8. Peanut lectin receptors in the early amphibian embryo: regional markers for the study of embryonic induction. Slack, J.M. Cell (1985) [Pubmed]
  9. Immunocytochemical localization of native chondroitin-sulfate in tissues and cultured cells using specific monoclonal antibody. Avnur, Z., Geiger, B. Cell (1984) [Pubmed]
  10. Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1. Höpker, V.H., Shewan, D., Tessier-Lavigne, M., Poo, M., Holt, C. Nature (1999) [Pubmed]
  11. Inhibition of tumor-cell-mediated extracellular matrix destruction by a fibroblast proteinase inhibitor, protease nexin I. Bergman, B.L., Scott, R.W., Bajpai, A., Watts, S., Baker, J.B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  12. Overexpression of matrix metalloproteinase-9 promotes intravascular thrombus formation in porcine coronary arteries in vivo. Morishige, K., Shimokawa, H., Matsumoto, Y., Eto, Y., Uwatoku, T., Abe, K., Sueishi, K., Takeshita, A. Cardiovasc. Res. (2003) [Pubmed]
  13. A metalloprotease from Xanthomonas campestris that specifically degrades proline/hydroxyproline-rich glycoproteins of the plant extracellular matrix. Dow, J.M., Davies, H.A., Daniels, M.J. Mol. Plant Microbe Interact. (1998) [Pubmed]
  14. Prelesional events in atherogenesis. Colocalization of apolipoprotein B, unesterified cholesterol and extracellular phospholipid liposomes in the aorta of hyperlipidemic rabbit. Mora, R., Lupu, F., Simionescu, N. Atherosclerosis (1987) [Pubmed]
  15. Involvement of diamine oxidase and peroxidase in insolubilization of the extracellular matrix: implications for pea nodule initiation by Rhizobium leguminosarum. Wisniewski, J.P., Rathbun, E.A., Knox, J.P., Brewin, N.J. Mol. Plant Microbe Interact. (2000) [Pubmed]
  16. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Mikecz, K., Brennan, F.R., Kim, J.H., Glant, T.T. Nat. Med. (1995) [Pubmed]
  17. Impaired wound healing in mice with a disrupted plasminogen gene. Romer, J., Bugge, T.H., Pyke, C., Lund, L.R., Flick, M.J., Degen, J.L., Dano, K. Nat. Med. (1996) [Pubmed]
  18. A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal system. Wu, V.M., Beitel, G.J. Curr. Opin. Cell Biol. (2004) [Pubmed]
  19. The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C. Varnum-Finney, B., Venstrom, K., Muller, U., Kypta, R., Backus, C., Chiquet, M., Reichardt, L.F. Neuron (1995) [Pubmed]
  20. Integrin-dependent actomyosin contraction regulates epithelial cell scattering. de Rooij, J., Kerstens, A., Danuser, G., Schwartz, M.A., Waterman-Storer, C.M. J. Cell Biol. (2005) [Pubmed]
  21. A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Richardson, A., Parsons, T. Nature (1996) [Pubmed]
  22. Heterogeneity of membrane phospholipid mobility in endothelial cells depends on cell substrate. Nakache, M., Schreiber, A.B., Gaub, H., McConnell, H.M. Nature (1985) [Pubmed]
  23. Sequence and domain structure of talin. Rees, D.J., Ades, S.E., Singer, S.J., Hynes, R.O. Nature (1990) [Pubmed]
  24. Interaction between a putative mechanosensory membrane channel and a collagen. Liu, J., Schrank, B., Waterston, R.H. Science (1996) [Pubmed]
  25. CD44 and its interaction with extracellular matrix. Lesley, J., Hyman, R., Kincade, P.W. Adv. Immunol. (1993) [Pubmed]
  26. Expression of human proteoglycan in Chinese hamster ovary cells inhibits cell proliferation. Yamaguchi, Y., Ruoslahti, E. Nature (1988) [Pubmed]
  27. Heparin inhibits the induction of three matrix metalloproteinases (stromelysin, 92-kD gelatinase, and collagenase) in primate arterial smooth muscle cells. Kenagy, R.D., Nikkari, S.T., Welgus, H.G., Clowes, A.W. J. Clin. Invest. (1994) [Pubmed]
  28. Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein. Jaźwińska, A., Ribeiro, C., Affolter, M. Nat. Cell Biol. (2003) [Pubmed]
  29. Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A. Huber, A.H., Wang, Y.M., Bieber, A.J., Bjorkman, P.J. Neuron (1994) [Pubmed]
  30. Requirement for integrins during Drosophila wing development. Brower, D.L., Jaffe, S.M. Nature (1989) [Pubmed]
  31. nompA encodes a PNS-specific, ZP domain protein required to connect mechanosensory dendrites to sensory structures. Chung, Y.D., Zhu, J., Han, Y., Kernan, M.J. Neuron (2001) [Pubmed]
  32. SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix. Sage, H., Vernon, R.B., Funk, S.E., Everitt, E.A., Angello, J. J. Cell Biol. (1989) [Pubmed]
  33. Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins. Czekay, R.P., Aertgeerts, K., Curriden, S.A., Loskutoff, D.J. J. Cell Biol. (2003) [Pubmed]
  34. The absence of nidogen 1 does not affect murine basement membrane formation. Murshed, M., Smyth, N., Miosge, N., Karolat, J., Krieg, T., Paulsson, M., Nischt, R. Mol. Cell. Biol. (2000) [Pubmed]
  35. Polarized fibronectin secretion and localized matrix assembly sites correlate with subendothelial matrix formation. Kowalczyk, A.P., Tulloh, R.H., McKeown-Longo, P.J. Blood (1990) [Pubmed]
  36. Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor. Mimuro, J., Schleef, R.R., Loskutoff, D.J. Blood (1987) [Pubmed]
  37. Polarized secretion of thrombospondin is opposite to thyroglobulin in thyroid epithelial cells. Prabakaran, D., Kim, P., Kim, K.R., Arvan, P. J. Biol. Chem. (1993) [Pubmed]
  38. Ascorbic acid modulates the production of fibronectin and laminin by cells from an eye tissue-trabecular meshwork. Yue, B.Y., Higginbotham, E.J., Chang, I.L. Exp. Cell Res. (1990) [Pubmed]
  39. Transcriptional activation of the matrix metalloproteinase gene stromelysin-3 coincides with thyroid hormone-induced cell death during frog metamorphosis. Patterton, D., Hayes, W.P., Shi, Y.B. Dev. Biol. (1995) [Pubmed]
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