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Gene Review

KIT  -  v-kit Hardy-Zuckerman 4 feline sarcoma...

Sus scrofa

 
 
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High impact information on KIT

  • Here, we describe that the dominant white phenotype in domestic pigs is caused by two mutations in the KIT gene encoding the mast/stem cell growth factor receptor (MGF), one gene duplication associated with a partially dominant phenotype and a splice mutation in one of the copies leading to the fully dominant allele [1].
  • Sequence analysis indicated that both MS16 and BA71V had significant deletions in the region containing members of multigene family 360 (MGF 360) and MGF530 [2].
  • Mutations in KIT encoding the mast/stem cell growth factor receptor (MGF) are responsible for coat color variation in domestic pigs [3].

References

  1. Molecular basis for the dominant white phenotype in the domestic pig. Marklund, S., Kijas, J., Rodriguez-Martinez, H., Rönnstrand, L., Funa, K., Moller, M., Lange, D., Edfors-Lilja, I., Andersson, L. Genome Res. (1998) [Pubmed]
  2. African swine fever virus multigene family 360 and 530 genes are novel macrophage host range determinants. Zsak, L., Lu, Z., Burrage, T.G., Neilan, J.G., Kutish, G.F., Moore, D.M., Rock, D.L. J. Virol. (2001) [Pubmed]
  3. Unexpectedly high allelic diversity at the KIT locus causing dominant white color in the domestic pig. Pielberg, G., Olsson, C., Syvänen, A.C., Andersson, L. Genetics (2002) [Pubmed]
 
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