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Gene Review:

GSTO1 - glutathione S-transferase omega 1

Sus scrofa

Synonyms: GSTO 1-1, SPG-R

Dulhunty, A. et al., Rouimi, P. et al., Washburn, M.P. et al.

Rouimi, Anglade, Benzekri, Costet, Debrauwer, Pineau, Tulliez,

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High impact information on GSTO1

The structural homology prompted us to investigate whether the human Omega class glutathione transferase GSTO1-1 forms or modulates ion channels [1].
We propose a novel role for GSTO1-1 in protecting cells containing RyR2 from apoptosis induced by Ca(2+) mobilization from intracellular stores [1].
We find that GSTO1-1 modulates ryanodine receptors (RyR), which are calcium channels in the endoplasmic reticulum of various cells [1].
The hepatic enzyme has been purified to homogeneity by using its selective affinity for S-hexylglutathione over GSH, thus providing a simple method to isolate mammalian GSTO [2].
The catalytic mechanism of the glutathione-dependent dehydroascorbate reductase activity of thioltransferase (glutaredoxin) [3].

References

The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. Dulhunty, A., Gage, P., Curtis, S., Chelvanayagam, G., Board, P. J. Biol. Chem. (2001) [Pubmed]
Purification and characterization of a glutathione S-transferase Omega in pig: evidence for two distinct organ-specific transcripts. Rouimi, P., Anglade, P., Benzekri, A., Costet, P., Debrauwer, L., Pineau, T., Tulliez, J. Biochem. J. (2001) [Pubmed]
The catalytic mechanism of the glutathione-dependent dehydroascorbate reductase activity of thioltransferase (glutaredoxin). Washburn, M.P., Wells, W.W. Biochemistry (1999) [Pubmed]

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