Gene Review:
RYR2 - ryanodine receptor 2 (cardiac)
Homo sapiens
Synonyms:
ARVC2, ARVD2, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, RYR-2, ...
- Denaturing HPLC-based approach for detecting RYR2 mutations involved in malignant arrhythmias. Bagattin, A., Veronese, C., Bauce, B., Wuyts, W., Settimo, L., Nava, A., Rampazzo, A., Danieli, G.A. Clin. Chem. (2004)
- Composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy. Milting, H., Lukas, N., Klauke, B., Körfer, R., Perrot, A., Osterziel, K.J., Vogt, J., Peters, S., Thieleczek, R., Varsányi, M. Cardiovasc. Res. (2006)
- Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Tiso, N., Stephan, D.A., Nava, A., Bagattin, A., Devaney, J.M., Stanchi, F., Larderet, G., Brahmbhatt, B., Brown, K., Bauce, B., Muriago, M., Basso, C., Thiene, G., Danieli, G.A., Rampazzo, A. Hum. Mol. Genet. (2001)
- Ryanodine receptor channelopathies. Benkusky, N.A., Farrell, E.F., Valdivia, H.H. Biochem. Biophys. Res. Commun. (2004)
- Screening for ryanodine receptor type 2 mutations in families with effort-induced polymorphic ventricular arrhythmias and sudden death: early diagnosis of asymptomatic carriers. Bauce, B., Rampazzo, A., Basso, C., Bagattin, A., Daliento, L., Tiso, N., Turrini, P., Thiene, G., Danieli, G.A., Nava, A. J. Am. Coll. Cardiol. (2002)
- Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Lehnart, S.E., Wehrens, X.H., Reiken, S., Warrier, S., Belevych, A.E., Harvey, R.D., Richter, W., Jin, S.L., Conti, M., Marks, A.R. Cell (2005)
- PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Marx, S.O., Reiken, S., Hisamatsu, Y., Jayaraman, T., Burkhoff, D., Rosemblit, N., Marks, A.R. Cell (2000)
- Cardiac and skeletal muscle disorders caused by mutations in the intracellular Ca2+ release channels. Priori, S.G., Napolitano, C. J. Clin. Invest. (2005)
- Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Wehrens, X.H., Marks, A.R. Trends Biochem. Sci. (2003)
- Isoform-specific interactions between halothane and the ryanodine receptor Ca(2+)-release channel: implications for malignant hyperthermia and the protein theory of anaesthetic action. Frömming, G.R., Ohlendieck, K. Naturwissenschaften (1999)
- Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death. Jiang, D., Wang, R., Xiao, B., Kong, H., Hunt, D.J., Choi, P., Zhang, L., Chen, S.R. Circ. Res. (2005)
- Adenosine A(2A) receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release. Hove-Madsen, L., Prat-Vidal, C., Llach, A., Ciruela, F., Casad??, V., Lluis, C., Bayes-Genis, A., Cinca, J., Franco, R. Cardiovasc. Res. (2006)
- Calcium channel antagonism reduces exercise-induced ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia patients with RyR2 mutations. Swan, H., Laitinen, P., Kontula, K., Toivonen, L. J. Cardiovasc. Electrophysiol. (2005)
- Molecular genetics of exercise-induced polymorphic ventricular tachycardia: identification of three novel cardiac ryanodine receptor mutations and two common calsequestrin 2 amino-acid polymorphisms. Laitinen, P.J., Swan, H., Kontula, K. Eur. J. Hum. Genet. (2003)
- Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6. George, C.H., Higgs, G.V., Mackrill, J.J., Lai, F.A. J. Biol. Chem. (2003)
- Expression of the ryanodine receptor isoforms in immune cells. Hosoi, E., Nishizaki, C., Gallagher, K.L., Wyre, H.W., Matsuo, Y., Sei, Y. J. Immunol. (2001)
- Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium. Awad, S.S., Lamb, H.K., Morgan, J.M., Dunlop, W., Gillespie, J.I. Biochem. J. (1997)
- Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. Zhao, F., Li, P., Chen, S.R., Louis, C.F., Fruen, B.R. J. Biol. Chem. (2001)
- Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites. Zhang, J., Liu, Z., Masumiya, H., Wang, R., Jiang, D., Li, F., Wagenknecht, T., Chen, S.R. J. Biol. Chem. (2003)
- The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different. Bultynck, G., Rossi, D., Callewaert, G., Missiaen, L., Sorrentino, V., Parys, J.B., De Smedt, H. J. Biol. Chem. (2001)
- In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. George, C.H., Sorathia, R., Bertrand, B.M., Lai, F.A. Biochem. J. (2003)
- Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. George, C.H., Higgs, G.V., Lai, F.A. Circ. Res. (2003)
- Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain. Zissimopoulos, S., Lai, F.A. J. Biol. Chem. (2005)
- Calmodulin regulation and identification of calmodulin binding region of type-3 ryanodine receptor calcium release channel. Yamaguchi, N., Xu, L., Pasek, D.A., Evans, K.E., Chen, S.R., Meissner, G. Biochemistry (2005)
- The glutathione transferase structural family includes a nuclear chloride channel and a ryanodine receptor calcium release channel modulator. Dulhunty, A., Gage, P., Curtis, S., Chelvanayagam, G., Board, P. J. Biol. Chem. (2001)
- Ryanodine receptors, FKBP12, and heart failure. Marks, A.R. Front. Biosci. (2002)
- Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors). Xiao, B., Masumiya, H., Jiang, D., Wang, R., Sei, Y., Zhang, L., Murayama, T., Ogawa, Y., Lai, F.A., Wagenknecht, T., Chen, S.R. J. Biol. Chem. (2002)
- A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP. Dulhunty, A.F., Pouliquin, P., Coggan, M., Gage, P.W., Board, P.G. Biochem. J. (2005)
- The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis. Tunwell, R.E., Wickenden, C., Bertrand, B.M., Shevchenko, V.I., Walsh, M.B., Allen, P.D., Lai, F.A. Biochem. J. (1996)
- Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. George, C.H., Jundi, H., Thomas, N.L., Scoote, M., Walters, N., Williams, A.J., Lai, F.A. Mol. Biol. Cell (2004)