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Gene Review

GSTO1  -  glutathione S-transferase omega 1

Homo sapiens

Synonyms: GSTO 1-1, GSTO-1, GSTTLP28, GSTTLp28, Glutathione S-transferase omega 1-1, ...
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Disease relevance of GSTO1


Psychiatry related information on GSTO1


High impact information on GSTO1


Chemical compound and disease context of GSTO1

  • Mice (BALB/c) were vaccinated with the HIV-1 gp120 envelope glycoprotein (Env(gp120)) alone or fused to multiple copies of the murine C3d or a twenty-eight amino-acid peptide (P28) containing a minimum CR2 binding domain [11].

Biological context of GSTO1


Anatomical context of GSTO1

  • Expression constructs were created for all eight nonsynonymous cSNPs, as well as a deletion of codon 155 in GSTO1, and those constructs were used to transfect COS-1 cells [13].
  • Rabbit reticulocyte lysate degradation studies showed that the GSTO1 Tyr32 and the GSTO2 Tyr130, Ile158, and Asp142/Ile158 variant allozymes were degraded more rapidly than were their respective WT allozymes [13].
  • We conclude that GSTO1 variants do not influence the risk for thyroid nodules or their pathologic and clinical characteristics [14].
  • After the neonatal production of CRE and the initiation of KIF3A loss, ectopic accumulation of opsin was detected by postnatal day (P)7, and ensuing photoreceptor cell death was evident after P10 and almost complete by P28 [15].
  • In contrast, a strong signal was apparent in the anterodorsal nucleus, which projects to limbic areas, and this persisted at P28 [16].

Associations of GSTO1 with chemical compounds


Other interactions of GSTO1

  • Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans [18].
  • CONCLUSION: The GSTO1 Asp allele may be a genetic risk factor for cerebrovascular diseases, and might influence the course of Alzheimer disease, even though effects vary in different studies [7].
  • We report the results of a screen for genetic association with urinary arsenic metabolite levels in three arsenic metabolism candidate genes, PNP, GSTO, and CYT19, in 135 arsenic-exposed subjects from the Yaqui Valley in Sonora, Mexico, who were exposed to drinking water concentrations ranging from 5.5 to 43.3 ppb [19].

Analytical, diagnostic and therapeutic context of GSTO1


  1. Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease. Arning, L., Jagiello, P., Wieczorek, S., Saft, C., Andrich, J., Epplen, J.T. BMC Med. Genet. (2004) [Pubmed]
  2. Polymorphism of glutathione S-transferase Omega gene and risk of cancer. Marahatta, S.B., Punyarit, P., Bhudisawasdi, V., Paupairoj, A., Wongkham, S., Petmitr, S. Cancer Lett. (2006) [Pubmed]
  3. Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin. Ridd, K., Zhang, S.D., Edwards, R.E., Davies, R., Greaves, P., Wolfreys, A., Smith, A.G., Gant, T.W. Carcinogenesis (2006) [Pubmed]
  4. Retroviral lineage analysis of fibroblast growth factor receptor signaling in FGF2 inhibition of oligodendrocyte progenitor differentiation. Zhou, Y.X., Flint, N.C., Murtie, J.C., Le, T.Q., Armstrong, R.C. Glia (2006) [Pubmed]
  5. Serology and leprosy: immunoassays comparing immunoglobulin G antibody responses to 28- and 30-kilodalton proteins purified from Mycobacterium bovis BCG. Pessolani, M.C., Peralta, J.M., Rumjanek, F.D., Gomes, H.M., Marques, M.A., Almeida, E.C., Saad, M.H., Sarno, E.N. J. Clin. Microbiol. (1991) [Pubmed]
  6. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. Ozturk, A., Desai, P.P., Minster, R.L., Dekosky, S.T., Kamboh, M.I. Neurobiol. Aging (2005) [Pubmed]
  7. Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke. Kölsch, H., Linnebank, M., Lütjohann, D., Jessen, F., Wüllner, U., Harbrecht, U., Thelen, K.M., Kreis, M., Hentschel, F., Schulz, A., von Bergmann, K., Maier, W., Heun, R. Neurology (2004) [Pubmed]
  8. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Li, Y.J., Oliveira, S.A., Xu, P., Martin, E.R., Stenger, J.E., Scherzer, C.R., Hauser, M.A., Scott, W.K., Small, G.W., Nance, M.A., Watts, R.L., Hubble, J.P., Koller, W.C., Pahwa, R., Stern, M.B., Hiner, B.C., Jankovic, J., Goetz, C.G., Mastaglia, F., Middleton, L.T., Roses, A.D., Saunders, A.M., Schmechel, D.E., Gullans, S.R., Haines, J.L., Gilbert, J.R., Vance, J.M., Pericak-Vance, M.A., Hulette, C., Welsh-Bohmer, K.A. Hum. Mol. Genet. (2003) [Pubmed]
  9. Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases. Li, Y.J., Scott, W.K., Zhang, L., Lin, P.I., Oliveira, S.A., Skelly, T., Doraiswamy, M.P., Welsh-Bohmer, K.A., Martin, E.R., Haines, J.L., Pericak-Vance, M.A., Vance, J.M. Neurobiol. Aging (2006) [Pubmed]
  10. Early-life immune challenge: defining a critical window for effects on adult responses to immune challenge. Spencer, S.J., Martin, S., Mouihate, A., Pittman, Q.J. Neuropsychopharmacology (2006) [Pubmed]
  11. A minimum CR2 binding domain of C3d enhances immunity following vaccination. Bower, J.F., Ross, T.M. Adv. Exp. Med. Biol. (2006) [Pubmed]
  12. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms. Whitbread, A.K., Tetlow, N., Eyre, H.J., Sutherland, G.R., Board, P.G. Pharmacogenetics (2003) [Pubmed]
  13. Glutathione S-transferase omega 1 and omega 2 pharmacogenomics. Mukherjee, B., Salavaggione, O.E., Pelleymounter, L.L., Moon, I., Eckloff, B.W., Schaid, D.J., Wieben, E.D., Weinshilboum, R.M. Drug Metab. Dispos. (2006) [Pubmed]
  14. GSTO polymorphism analysis in thyroid nodules suggest that GSTO1 variants do not influence the risk for malignancy. Granja, F., Morari, E.C., Assumpção, L.V., Ward, L.S. Eur. J. Cancer Prev. (2005) [Pubmed]
  15. Analysis of Kinesin-2 Function in Photoreceptor Cells Using Synchronous Cre-loxP Knockout of Kif3a with RHO-Cre. Jimeno, D., Feiner, L., Lillo, C., Teofilo, K., Goldstein, L.S., Pierce, E.A., Williams, D.S. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  16. Transient synaptic zinc-positive thalamocortical terminals in the developing barrel cortex. Ichinohe, N., Potapov, D., Rockland, K.S. Eur. J. Neurosci. (2006) [Pubmed]
  17. Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn). Tanaka-Kagawa, T., Jinno, H., Hasegawa, T., Makino, Y., Seko, Y., Hanioka, N., Ando, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  18. Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans. Yu, L., Kalla, K., Guthrie, E., Vidrine, A., Klimecki, W.T. Environ. Health Perspect. (2003) [Pubmed]
  19. Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children. Meza, M.M., Yu, L., Rodriguez, Y.Y., Guild, M., Thompson, D., Gandolfi, A.J., Klimecki, W.T. Environ. Health Perspect. (2005) [Pubmed]
  20. Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice: Enzyme and arsenic species concentrations in tissues after arsenate administration. Chowdhury, U.K., Zakharyan, R.A., Hernandez, A., Avram, M.D., Kopplin, M.J., Aposhian, H.V. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  21. Characterization of the omega class of glutathione transferases. Whitbread, A.K., Masoumi, A., Tetlow, N., Schmuck, E., Coggan, M., Board, P.G. Meth. Enzymol. (2005) [Pubmed]
  22. CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels. Board, P.G., Coggan, M., Watson, S., Gage, P.W., Dulhunty, A.F. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  23. Vector-Mediated Delivery of bcl-2 Prevents Degeneration of Auditory Hair Cells and Neurons after Injury. Staecker, H., Liu, W., Malgrange, B., Lefebvre, P.P., Van De Water, T.R. ORL J. Otorhinolaryngol. Relat. Spec. (2007) [Pubmed]
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