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Gene Review

IL1B1  -  interleukin 1, beta 1

Sus scrofa

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High impact information on IL1B

  • A genomic clone (PIL3) covering the 8.8-kb prointerleukin-1 beta ('catabolin') gene of the domesticated swine (Sus scrofa domestica) was isolated from a genomic library and characterized by nucleotide sequencing [1].
  • Administration of pINA, however, did correlate with decreased IL1B secretion by cultured, unstimulated PBMC but had no effect on their ability to release IFNG [2].


  1. Gene sequence, cDNA construction, expression in Escherichia coli and genetically approached purification of porcine interleukin-1 beta. Vandenbroeck, K., Fiten, P., Beuken, E., Martens, E., Janssen, A., Van Damme, J., Opdenakker, G., Billiau, A. Eur. J. Biochem. (1993) [Pubmed]
  2. Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination. Royaee, A.R., Husmann, R.J., Dawson, H.D., Calzada-Nova, G., Schnitzlein, W.M., Zuckermann, F.A., Lunney, J.K. Vet. Immunol. Immunopathol. (2004) [Pubmed]
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