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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

IFNG  -  interferon, gamma

Sus scrofa

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Disease relevance of IFNG


High impact information on IFNG


Chemical compound and disease context of IFNG


Biological context of IFNG

  • Furthermore, the genes for mucin and interferon gamma were physically localized to porcine chromosome 5q2.3 and 5p1.2-q1.1 by fluorescence and radioactive in situ hybridization, respectively, thereby assigning four new markers to chromosome 5 [14].
  • The compound microsatellites IFNG and S0215 were unaffected by size homoplasy (SH) within our material [15].
  • Efforts to enhance Th1 immunity, by utilizing an expression plasmid encoding porcine IFNA (pINA) as an adjuvant, resulted in a temporary increase in the frequency of PRRSV-specific IFNG SC but only minor changes overall in the expression of Th1 associated cytokine or innate immune marker mRNA by virus-stimulated PBMC [16].
  • Induction of the IFN-gamma gene and protein is linked to the establishment of cell polarity in a porcine epithelial cell line [17].
  • Interferon-gamma gene and protein are spontaneously expressed by the porcine trophectoderm early in gestation [18].

Anatomical context of IFNG


Associations of IFNG with chemical compounds


Regulatory relationships of IFNG


Other interactions of IFNG

  • Administration of pINA, however, did correlate with decreased IL1B secretion by cultured, unstimulated PBMC but had no effect on their ability to release IFNG [16].
  • PROCEDURE: Alveolar macrophages were incubated for 48 hours with APP (1 X 10(4) colony-forming units/mL), interleukin-1beta, (IL-1beta; 5 U/mL), tumor necrosis factor-alpha (TNFalpha; 500 U/mL), interferon-gamma (IFN-gamma, 100 U/mL), or lipopolysaccharide (LPS; 10 microg/mL) [29].
  • Thus, when induced by IFN-gamma or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response [30].
  • A strong correlation between rejection and up-regulation of the IFN-gamma gene was observed, whereas animals with long-term tolerance showed low levels of IFN-gamma, but high levels of IL-10 gene transcription [31].
  • This is a simple method that allows reliable determination of the differing regulation of cytokine mRNAs specific for porcine interleukin (IL)-2, -4 and -10, interferon gamma (IFN-gamma) and the housekeeping gene, GAPDH, as an endogenous control [32].

Analytical, diagnostic and therapeutic context of IFNG


  1. Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination. Meier, W.A., Galeota, J., Osorio, F.A., Husmann, R.J., Schnitzlein, W.M., Zuckermann, F.A. Virology (2003) [Pubmed]
  2. Effect of interferon-alpha, interferon-gamma and tumour necrosis factor on African swine fever virus replication in porcine monocytes and macrophages. Esparza, I., González, J.C., Viñuela, E. J. Gen. Virol. (1988) [Pubmed]
  3. Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. Hontecillas, R., Wannemeulher, M.J., Zimmerman, D.R., Hutto, D.L., Wilson, J.H., Ahn, D.U., Bassaganya-Riera, J. J. Nutr. (2002) [Pubmed]
  4. Engineering by PCR-based exon amplification of the genomic porcine interferon-gamma DNA for expression in Escherichia coli. Vandenbroeck, K., Dijkmans, R., van Aerschot, A., Billiau, A. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  5. Recombinant porcine IFN-gamma potentiates the secondary IgG and IgA responses to an inactivated suid herpesvirus-1 vaccine and reduces postchallenge weight loss and fever in pigs. Vandenbroeck, K., Nauwynck, H., Vanderpooten, A., Van Reeth, K., Goddeeris, B., Billiau, A. J. Interferon Cytokine Res. (1998) [Pubmed]
  6. A newly defined property of somatotropin: priming of macrophages for production of superoxide anion. Edwards, C.K., Ghiasuddin, S.M., Schepper, J.M., Yunger, L.M., Kelley, K.W. Science (1988) [Pubmed]
  7. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Murray, A.G., Khodadoust, M.M., Pober, J.S., Bothwell, A.L. Immunity (1994) [Pubmed]
  8. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Radomski, M.W., Palmer, R.M., Moncada, S. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  9. Intensity and mechanisms of in vitro xenorecognition of adult pig pancreatic islet cells by CD4+ and CD8+ lymphocytes from type I diabetic or healthy subjects. Lalain, S., Chaillous, L., Gouin, E., Saï, P. Diabetologia (1999) [Pubmed]
  10. Changes in swine macrophage phenotype after infection with African swine fever virus: cytokine production and responsiveness to interferon-gamma and lipopolysaccharide. Whittall, J.T., Parkhouse, R.M. Immunology (1997) [Pubmed]
  11. Circulating cortisol, tumor necrosis factor-alpha interleukin-1beta, and interferon-gamma in pigs infected with Actinobacillus pleuropneumoniae. Balaji, R., Wright, K.J., Turner, J.L., Hill, C.M., Dritz, S.S., Fenwick, B., Carrollt, J.A., Zannelli, M.E., Beausang, L.A., Minton, J.E. J. Anim. Sci. (2002) [Pubmed]
  12. Vitamin E supplementation does not mitigate the acute morbidity effects of porcine reproductive and respiratory syndrome virus in nursery pigs. Toepfer-Berg, T.L., Escobar, J., Van Alstine, W.G., Baker, D.H., Salak-Johnson, J., Johnson, R.W. J. Anim. Sci. (2004) [Pubmed]
  13. Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide. Jung, K., Ha, Y., Ha, S.K., Han, D.U., Kim, D.W., Moon, W.K., Chae, C. J. Vet. Med. B Infect. Dis. Vet. Public Health (2004) [Pubmed]
  14. Genetic analysis of the gene for porcine submaxillary gland mucin: physical assignment of the MUC and interferon gamma genes to chromosome 5. Johansson, M., Chowdhary, B., Gu, F., Ellegren, H., Gustavsson, I., Andersson, L. J. Hered. (1993) [Pubmed]
  15. Nine porcine microsatellite loci tested for size homoplasy in genetically diverse breeds. Peischl, T., Kuss, A.W., Melchinger-Wild, E., Geldermann, H. Anim. Genet. (2005) [Pubmed]
  16. Deciphering the involvement of innate immune factors in the development of the host response to PRRSV vaccination. Royaee, A.R., Husmann, R.J., Dawson, H.D., Calzada-Nova, G., Schnitzlein, W.M., Zuckermann, F.A., Lunney, J.K. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  17. Induction of the IFN-gamma gene and protein is linked to the establishment of cell polarity in a porcine epithelial cell line. Marcelo, P., Lefèvre, F. Exp. Cell Res. (2002) [Pubmed]
  18. Interferon-gamma gene and protein are spontaneously expressed by the porcine trophectoderm early in gestation. Lefèvre, F., Martinat-Botté, F., Guillomot, M., Zouari, K., Charley, B., La Bonnardière, C. Eur. J. Immunol. (1990) [Pubmed]
  19. Interferon gamma bound to extracellular matrix changes the hyporesponsiveness to LPS in crypt but not villous intestinal epithelial cells. Alvarado, J., Taylor, P., Castillo, J.R., Thomas, L.E. Immunol. Lett. (2005) [Pubmed]
  20. Identification of key immune mediators regulating T helper 1 responses in swine. Dawson, H.D., Royaee, A.R., Nishi, S., Kuhar, D., Schnitzlein, W.M., Zuckermann, F., Urban, J., Lunney, J.K. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  21. Activation of primary porcine endothelial cells induces release of porcine endogenous retroviruses. Cunningham, D.A., Dos Santos Cruz, G.J., Fernández-Suárez, X.M., Whittam, A.J., Herring, C., Copeman, L., Richards, A., Langford, G.A. Transplantation (2004) [Pubmed]
  22. Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor. Gilli, U.O., Schneider, M.K., Loetscher, P., Seebach, J.D. Transplantation (2005) [Pubmed]
  23. Ovarian actions of tumor necrosis factor-alpha (TNF alpha): pleiotropic effects of TNF alpha on differentiated functions of untransformed swine granulosa cells. Veldhuis, J.D., Garmey, J.C., Urban, R.J., Demers, L.M., Aggarwal, B.B. Endocrinology (1991) [Pubmed]
  24. Refolding and single-step purification of porcine interferon-gamma from Escherichia coli inclusion bodies. Conditions for reconstitution of dimeric IFN-gamma. Vandenbroeck, K., Martens, E., D'Andrea, S., Billiau, A. Eur. J. Biochem. (1993) [Pubmed]
  25. Beta-glucan enhancement of T cell IFNgamma response in swine. Xiao, Z., Trincado, C.A., Murtaugh, M.P. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  26. Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-gamma in primary pig adipocytes. Ajuwon, K.M., Jacobi, S.K., Kuske, J.L., Spurlock, M.E. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  27. IFN-gamma gene expression in epithelial trophectoderm cells is linked to downregulation of the p44/p42 MAP kinase pathway. Marcelo, P., Lefèvre, F. J. Interferon Cytokine Res. (2004) [Pubmed]
  28. Porcine interleukin-12 fusion protein and interleukin-18 in combination induce interferon-gamma production in porcine natural killer and T cells. Domeika, K., Berg, M., Eloranta, M.L., Alm, G.V. Vet. Immunol. Immunopathol. (2002) [Pubmed]
  29. In vitro effects of Actinobacillus pleuropneumoniae on inducible nitric oxide synthase and cyclooxygenase-2 in porcine alveolar macrophages. Cho, W.S., Chae, C. Am. J. Vet. Res. (2003) [Pubmed]
  30. Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes. Ajuwon, K.M., Spurlock, M.E. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004) [Pubmed]
  31. Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine. Blancho, G., Gianello, P.R., Lorf, T., Germana, S., Giangrande, I., Mourad, G., Colvin, R.B., Sachs, D.H., LeGuern, C. Transplantation (1997) [Pubmed]
  32. T helper 1-type cytokine transcription in peripheral blood mononuclear cells of pseudorabies virus (Suid herpesvirus 1)-primed swine indicates efficient immunization. Fischer, T., Büttner, M., Rziha, H.J. Immunology (2000) [Pubmed]
  33. NO and TNF-alpha released from activated macrophages stabilize HIF-1alpha in resting tubular LLC-PK1 cells. Zhou, J., Fandrey, J., Schümann, J., Tiegs, G., Brüne, B. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  34. Paracrine activities of porcine trophoblastic interferons. D'Andrea, S., Chousterman, S., Flechon, J.E., La Bonnardière, C. J. Reprod. Fertil. (1994) [Pubmed]
  35. Histomorphometric comparison of cardiac allograft vasculopathy in miniature swine. Houser, S.L., McMorrow, I.M., LeGuern, C., Schwarze, M.L., Fuchimoto, Y., Sachs, D.H., Madsen, J.C. J. Heart Lung Transplant. (2004) [Pubmed]
  36. Systemic and mucosal immune responses to H1N1 influenza virus infection in pigs. Larsen, D.L., Karasin, A., Zuckermann, F., Olsen, C.W. Vet. Microbiol. (2000) [Pubmed]
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