Gene Review:
IL1B - interleukin 1, beta
Homo sapiens
Synonyms:
Catabolin, IL-1, IL-1 beta, IL-1B, IL1-BETA, ...
Meulenbelt,
Seymour,
Nieuwland,
Huizinga,
van Duijn,
Slagboom,
Queiroz,
Guerra,
Rocha,
Rocha,
Santos,
De Oliveira,
Cabral,
Nogueira,
De Oliveira,
González,
Sala,
Capellá,
Carter,
Jones,
Camp,
Cox,
Mee,
Warren,
Duff,
Lobo,
di Giovine,
Addas-Carvalho,
Origa,
Saad,
Maksymowych,
Rahman,
Reeve,
Gladman,
Peddle,
Inman,
Hefler,
Tempfer,
Bashford,
Unfried,
Zeillinger,
Schneeberger,
Koelbl,
Nagele,
Huber,
- IL1B and IL1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis. Queiroz, D.M., Guerra, J.B., Rocha, G.A., Rocha, A.M., Santos, A., De Oliveira, A.G., Cabral, M.M., Nogueira, A.M., De Oliveira, C.A. Gastroenterology (2004)
- Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. Meulenbelt, I., Seymour, A.B., Nieuwland, M., Huizinga, T.W., van Duijn, C.M., Slagboom, P.E. Arthritis Rheum. (2004)
- Genetic susceptibility and gastric cancer risk. González, C.A., Sala, N., Capellá, G. Int. J. Cancer (2002)
- Association of interleukin-1beta gene polymorphisms with precancerous gastric lesions in African Americans and Caucasians. Zabaleta, J., Camargo, M.C., Piazuelo, M.B., Fontham, E., Schneider, B.G., Sicinschi, L.A., Ferrante, W., Balart, L., Correa, P., Ochoa, A.C. Am. J. Gastroenterol. (2006)
- Association of IL-1 RN*2 allele and methionine synthase 2756 AA genotype with dementia severity of sporadic Alzheimer's disease. Bosco, P., Guéant-Rodríguez, R.M., Anello, G., Romano, A., Namour, B., Spada, R.S., Caraci, F., Tringali, G., Ferri, R., Guéant, J.L. J. Neurol. Neurosurg. Psychiatr. (2004)
- Tumor necrosis factor-alpha: is there a continuum of liability between stress, anxiety states and anorexia nervosa? Holden, R.J., Pakula, I.S. Med. Hypotheses (1999)
- Interactions between HIV-infected monocyte-derived macrophages and human brain microvascular endothelial cells result in increased expression of CC chemokines. Boven, L.A., Middel, J., Breij, E.C., Schotte, D., Verhoef, J., Soderland, C., Nottet, H.S. J. Neurovirol. (2000)
- Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats. Bluthé, R.M., Beaudu, C., Kelley, K.W., Dantzer, R. Brain Res. (1995)
- Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. Gallo, P., Frei, K., Rordorf, C., Lazdins, J., Tavolato, B., Fontana, A. J. Neuroimmunol. (1989)
- Role of cytokines in rheumatoid arthritis. Feldmann, M., Brennan, F.M., Maini, R.N. Annu. Rev. Immunol. (1996)
- The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. Endres, S., Ghorbani, R., Kelley, V.E., Georgilis, K., Lonnemann, G., van der Meer, J.W., Cannon, J.G., Rogers, T.S., Klempner, M.S., Weber, P.C. N. Engl. J. Med. (1989)
- Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Osborn, L., Hession, C., Tizard, R., Vassallo, C., Luhowskyj, S., Chi-Rosso, G., Lobb, R. Cell (1989)
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Wang, C., Deng, L., Hong, M., Akkaraju, G.R., Inoue , J., Chen, Z.J. Nature (2001)
- A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Thornberry, N.A., Bull, H.G., Calaycay, J.R., Chapman, K.T., Howard, A.D., Kostura, M.J., Miller, D.K., Molineaux, S.M., Weidner, J.R., Aunins, J. Nature (1992)
- Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Casey, L.C., Balk, R.A., Bone, R.C. Ann. Intern. Med. (1993)
- Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells. de-Mello, M.A., Flodström, M., Eizirik, D.L. Biochem. Pharmacol. (1996)
- Interleukin-1 beta stimulates cell proliferation in the intermediate lobe of the rat pituitary gland. Stepień, H., Zerek-Mełen, G., Mucha, S., Winczyk, K., Fryczak, J. J. Endocrinol. (1994)
- Inflammatory mediators of the terminal dentition in adult and early onset periodontitis. Salvi, G.E., Brown, C.E., Fujihashi, K., Kiyono, H., Smith, F.W., Beck, J.D., Offenbacher, S. J. Periodont. Res. (1998)
- Prostaglandin E2 and I2 regulate intercellular adhesion molecule-1 expression in interleukin-1 beta-stimulated human gingival fibroblasts. Iwasaki, K., Noguchi, K., Ishikawa, I. J. Periodont. Res. (1999)
- Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin-1beta gene through association with two transcription factors, nuclear factor-interleukin-6 and Spi-1. Tsukada, J., Misago, M., Serino, Y., Ogawa, R., Murakami, S., Nakanishi, M., Tonai, S., Kominato, Y., Morimoto, I., Auron, P.E., Eto, S. Blood (1997)
- Autocrine induction of the human pro-IL-1beta gene promoter by IL-1beta in monocytes. Toda, Y., Tsukada, J., Misago, M., Kominato, Y., Auron, P.E., Tanaka, Y. J. Immunol. (2002)
- Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein. Hall, S.K., Perregaux, D.G., Gabel, C.A., Woodworth, T., Durham, L.K., Huizinga, T.W., Breedveld, F.C., Seymour, A.B. Arthritis Rheum. (2004)
- Association of the IL1 gene cluster with susceptibility to ankylosing spondylitis: an analysis of three Canadian populations. Maksymowych, W.P., Rahman, P., Reeve, J.P., Gladman, D.D., Peddle, L., Inman, R.D. Arthritis Rheum. (2006)
- T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Wang, Z.C., Yunis, E.J., De los Santos, M.J., Xiao, L., Anderson, D.J., Hill, J.A. Genes Immun. (2002)
- The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. Marotte, H., Farge, P., Gaudin, P., Alexandre, C., Mougin, B., Miossec, P. Ann. Rheum. Dis. (2006)
- Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Housby, J.N., Cahill, C.M., Chu, B., Prevelige, R., Bickford, K., Stevenson, M.A., Calderwood, S.K. Cytokine (1999)
- Interleukin-1 receptor antagonist. Arend, W.P. Adv. Immunol. (1993)
- Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. Genis, P., Jett, M., Bernton, E.W., Boyle, T., Gelbard, H.A., Dzenko, K., Keane, R.W., Resnick, L., Mizrachi, Y., Volsky, D.J. J. Exp. Med. (1992)
- Proinflammatory cytokines found in amniotic fluid induce collagen remodeling, apoptosis, and biophysical weakening of cultured human fetal membranes. Kumar, D., Fung, W., Moore, R.M., Pandey, V., Fox, J., Stetzer, B., Mansour, J.M., Mercer, B.M., Redline, R.W., Moore, J.J. Biol. Reprod. (2006)
- -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone. Corral-Gudino, L., del Pino-Montes, J., García-Aparicio, J., Corral, E., Montilla, C.A., González-Sarmiento, R. Bone (2006)
- Glucocorticoid inhibits the human pro-interleukin lbeta gene (ILIB) by decreasing DNA binding of transactivators to the signal-responsive enhancer. Waterman, W.R., Xu, L.L., Tetradis, S., Motyckova, G., Tsukada, J., Saito, K., Webb, A.C., Robinson, D.R., Auron, P.E. Mol. Immunol. (2006)
- Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes. Granowitz, E.V., Clark, B.D., Vannier, E., Callahan, M.V., Dinarello, C.A. Blood (1992)
- Site-directed mutagenesis--molecular biology and rational drug design. Ju, G., Labriola-Tompkins, E., Varnell, T., Madison, V., Graves, B. Agents Actions Suppl. (1995)
- Heterogeneity in interleukin (IL)-1 receptors expressed on human B cell lines. Differences in the molecular properties of IL-1 alpha and IL-1 beta binding sites. Benjamin, D., Wormsley, S., Dower, S.K. J. Biol. Chem. (1990)
- Antibodies to domains II and III of the IL-1 receptor accessory protein inhibit IL-1 beta activity but not binding: regulation of IL-1 responses is via type I receptor, not the accessory protein. Yoon, D.Y., Dinarello, C.A. J. Immunol. (1998)
- Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669. Kracht, M., Shiroo, M., Marshall, C.J., Hsuan, J.J., Saklatvala, J. Biochem. J. (1994)
- Negative regulation of toll-like receptor-mediated signaling by Tollip. Zhang, G., Ghosh, S. J. Biol. Chem. (2002)
- Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. Lippke, J.A., Gu, Y., Sarnecki, C., Caron, P.R., Su, M.S. J. Biol. Chem. (1996)
- Production, purification, and crystallization of human interleukin-1 beta converting enzyme derived from an Escherichia coli expression system. Malinowski, J.J., Grasberger, B.L., Trakshel, G., Huston, E.E., Helaszek, C.T., Smallwood, A.M., Ator, M.A., Banks, T.M., Brake, P.G., Ciccarelli, R.B. Protein Sci. (1995)
- Assay for IkappaB kinases using an in vivo biotinylated IkappaB protein substrate. Wisniewski, D., LoGrasso, P., Calaycay, J., Marcy, A. Anal. Biochem. (1999)
- Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. Marui, N., Offermann, M.K., Swerlick, R., Kunsch, C., Rosen, C.A., Ahmad, M., Alexander, R.W., Medford, R.M. J. Clin. Invest. (1993)
- Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts. Kumar, S., Millis, A.J., Baglioni, C. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist. Vannier, E., Miller, L.C., Dinarello, C.A. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop. Hiscott, J., Marois, J., Garoufalis, J., D'Addario, M., Roulston, A., Kwan, I., Pepin, N., Lacoste, J., Nguyen, H., Bensi, G. Mol. Cell. Biol. (1993)
- Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. March, C.J., Mosley, B., Larsen, A., Cerretti, D.P., Braedt, G., Price, V., Gillis, S., Henney, C.S., Kronheim, S.R., Grabstein, K. Nature (1985)
- Leukocyte activation in the peripheral blood of patients with cirrhosis of the liver and SIRS. Correlation with serum interleukin-6 levels and organ dysfunction. Rosenbloom, A.J., Pinsky, M.R., Bryant, J.L., Shin, A., Tran, T., Whiteside, T. JAMA (1995)
- Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide. Cassatella, M.A., Meda, L., Bonora, S., Ceska, M., Constantin, G. J. Exp. Med. (1993)
- Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between interferon-gamma and tumor necrosis factor-alpha on HLA-DR expression, proliferation, collagenase production, and granulocyte macrophage colony-stimulating factor production by rheumatoid arthritis synoviocytes. Alvaro-Gracia, J.M., Zvaifler, N.J., Firestein, G.S. J. Clin. Invest. (1990)
- Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis. Carter, M.J., Jones, S., Camp, N.J., Cox, A., Mee, J., Warren, B., Duff, G.W., Lobo, A.J., di Giovine, F.S. Genes Immun. (2004)
- Interleukin 1 beta and tumor necrosis factor levels in stored platelet concentrates and the association with gene polymorphisms. Addas-Carvalho, M., Origa, A.F., Saad, S.T. Transfusion (2004)
- Polymorphisms of the angiotensinogen gene, the endothelial nitric oxide synthase gene, and the interleukin-1beta gene promoter in women with idiopathic recurrent miscarriage. Hefler, L.A., Tempfer, C.B., Bashford, M.T., Unfried, G., Zeillinger, R., Schneeberger, C., Koelbl, H., Nagele, F., Huber, J.C. Mol. Hum. Reprod. (2002)
- Interleukin-8 gene expression by a pulmonary epithelial cell line. A model for cytokine networks in the lung. Standiford, T.J., Kunkel, S.L., Basha, M.A., Chensue, S.W., Lynch, J.P., Toews, G.B., Westwick, J., Strieter, R.M. J. Clin. Invest. (1990)