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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IHH  -  Indian hedgehog

Sus scrofa

 
 
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Disease relevance of IHH

  • More severe respiratory acidosis developed when IHH was delivered in intermediate (4 min or 8 min) cycles compared with the same total dose as a single episode or in short (2 min) cycles [1].
  • Despite this, piglets in these intermediate intermittent HH (IHH) groups (8- and 4-min cycles) showed more severe acidosis and attenuated temperature changes (P < 0.001 and P < 0.01 for pH and temperature vs. 24 min, respectively) [1].
 

High impact information on IHH

  • METHODS: Pigs underwent IHHP with TNF, melphalan, and MMC using balloon catheters or served as controls, receiving equivalent dosages of these agents intravenously [2].
 

Analytical, diagnostic and therapeutic context of IHH

  • OBJECTIVE: To validate the methodology of isolated hypoxic hepatic perfusion (IHHP) using balloon catheter techniques and to gain insight into the distribution of tumor necrosis factor-alpha (TNF), melphalan, and mitomycin C (MMC) through the regional and systemic blood compartments when applying these techniques [2].

References

  1. Effect of stimulus cycle time on acute respiratory responses to intermittent hypercapnic hypoxia in unsedated piglets. Waters, K.A., Tinworth, K.D. J. Appl. Physiol. (2003) [Pubmed]
  2. Isolated hypoxic hepatic perfusion with tumor necrosis factor-alpha, melphalan, and mitomycin C using balloon catheter techniques: a pharmacokinetic study in pigs. van Ijken, M.G., de Bruijn, E.A., de Boeck, G., ten Hagen, T.L., van der Sijp, J.R., Eggermont, A.M. Ann. Surg. (1998) [Pubmed]
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