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Disease relevance of Acidosis


Psychiatry related information on Acidosis


High impact information on Acidosis

  • P2-purinergic stimulation increases cAMP by activating adenylyl cyclase isoform V. It also involves tyrosine kinases to activate phospholipase C-gamma to produce inositol 1,4,5-trisphosphate and Cl(-)/HCO(3)(-) exchange to induce a large transient acidosis [11].
  • Here, we show that acidosis activates Ca2+ -permeable acid-sensing ion channels (ASICs), inducing glutamate receptor-independent, Ca2+ -dependent, neuronal injury inhibited by ASIC blockers [12].
  • BACKGROUND: Methanol poisoning may result in metabolic acidosis, blindness, and death [13].
  • The outcomes measured were the preservation of visual acuity, the resolution of metabolic acidosis, the inhibition of formic acid production, the achievment of therapeutic plasma concentrations of fomepizole with the dosing regimen, residual illness or disability, and death [13].
  • Ant1 mutant adults also had a resting serum lactate level fourfold higher than that of controls, indicative of metabolic acidosis [14].

Chemical compound and disease context of Acidosis

  • The spontaneous resolution of the acidosis was due, in large part, to the metabolism of lactate and to the concomitant removal of hydrogen ion [15].
  • These results indicate that severe cholera causes acidosis with relatively little change in serum chloride but an increased serum anion gap [16].
  • Editorial: Aldosterone, potassium and acidosis [17].
  • In the remaining eight patients, the urinary pH did not fall below 5.5 (6.4 +/- 0.2) with acidosis, and we failed to lower the urinary pH and increase fractional potassium excretion to normal by administering a mineralocorticoid and sodium sulfate [18].
  • In view of the sensitivity of ion channels and intracellular ion concentrations to changes in pHi, a GABA-induced postsynaptic acidosis could prove to be important in the modulation of inhibitory transmission [19].

Biological context of Acidosis


Anatomical context of Acidosis


Gene context of Acidosis


Analytical, diagnostic and therapeutic context of Acidosis

  • Ammonia entry along surface nephron segments of rats was studied with micropuncture techniques under control and chronic metabolic acidosis conditions [34].
  • A higher degree of protection was observed when the prostaglandin was dissolved in 0.16 M HCO3-. Intraarterial infusion of high concentrations of bicarbonate completely eliminated acidosis with ulceration occurring in 1 of 6 rats infused with 0.5 M and in 1 of 10 with 1 M bicarbonate [26].
  • Moon facies and hyperkalemic metabolic acidosis were also present in this patient, features uncommonly seen in the actopic ACTH syndrome [35].
  • We recommend prompt hemodialysis if the blood methanol level is above 50 mg/dl, when an amount of methanol exceeding the minimal lethal dose (30 ml) is known to have been ingested, when there is evidence of acidosis or when an abnormality has developed in vision, funduscopic examination or mental state [36].
  • Oral rehydration therapy: efficacy of sodium citrate equals to sodium bicarbonate for correction of acidosis in diarrhoea [37].


  1. Chronic respiratory alkalosis. The effect of sustained hyperventilation on renal regulation of acid-base equilibrium. Krapf, R., Beeler, I., Hertner, D., Hulter, H.N. N. Engl. J. Med. (1991) [Pubmed]
  2. Mutations in the gene encoding B1 subunit of H+-ATPase cause renal tubular acidosis with sensorineural deafness. Karet, F.E., Finberg, K.E., Nelson, R.D., Nayir, A., Mocan, H., Sanjad, S.A., Rodriguez-Soriano, J., Santos, F., Cremers, C.W., Di Pietro, A., Hoffbrand, B.I., Winiarski, J., Bakkaloglu, A., Ozen, S., Dusunsel, R., Goodyer, P., Hulton, S.A., Wu, D.K., Skvorak, A.B., Morton, C.C., Cunningham, M.J., Jha, V., Lifton, R.P. Nat. Genet. (1999) [Pubmed]
  3. Amelioration of metabolic acidosis with fludrocortisone therapy in hyporeninemic hypoaldosteronism. Sebastian, A., Schambelan, M., Lindenfeld, S., Morris, R.C. N. Engl. J. Med. (1977) [Pubmed]
  4. Phenformin and lactic acidosis. Conlay, L.A., Loewenstein, J.E. JAMA (1976) [Pubmed]
  5. Parallel adaptation of the rabbit renal cortical sodium/proton antiporter and sodium/bicarbonate cotransporter in metabolic acidosis and alkalosis. Akiba, T., Rocco, V.K., Warnock, D.G. J. Clin. Invest. (1987) [Pubmed]
  6. Chronic salicylate poisoning and severe malaria. English, M., Marsh, V., Amukoye, E., Lowe, B., Murphy, S., Marsh, K. Lancet (1996) [Pubmed]
  7. Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy. Pannunzio, P., Hazell, A.S., Pannunzio, M., Rao, K.V., Butterworth, R.F. J. Neurosci. Res. (2000) [Pubmed]
  8. Implications of lower- and upper-limb training procedures in patients with chronic airway obstruction. Gimenez, M., Predine, E., Marchand, M., Servera, E., Ponz, J.L., Polu, J.M. Chest (1992) [Pubmed]
  9. Acquired nephrogenic diabetes insipidus secondary to distal renal tubular acidosis and nephrocalcinosis associated with Sjögren's syndrome. Nagayama, Y., Shigeno, M., Nakagawa, Y., Suganuma, A., Takeshita, A., Fujiyama, K., Ashizawa, K., Kiriyama, T., Yokoyama, N., Nagataki, S. J. Endocrinol. Invest. (1994) [Pubmed]
  10. Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats. Rosa, R.B., Schuck, P.F., de Assis, D.R., Latini, A., Dalcin, K.B., Ribeiro, C.A., da C Ferreira, G., Maria, R.C., Leipnitz, G., Perry, M.L., Filho, C.S., Wyse, A.T., Wannmacher, C.M., Wajner, M. J. Inherit. Metab. Dis. (2005) [Pubmed]
  11. Adenosine 5'-triphosphate: a P2-purinergic agonist in the myocardium. Vassort, G. Physiol. Rev. (2001) [Pubmed]
  12. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Xiong, Z.G., Zhu, X.M., Chu, X.P., Minami, M., Hey, J., Wei, W.L., MacDonald, J.F., Wemmie, J.A., Price, M.P., Welsh, M.J., Simon, R.P. Cell (2004) [Pubmed]
  13. Fomepizole for the treatment of methanol poisoning. Brent, J., McMartin, K., Phillips, S., Aaron, C., Kulig, K. N. Engl. J. Med. (2001) [Pubmed]
  14. A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Graham, B.H., Waymire, K.G., Cottrell, B., Trounce, I.A., MacGregor, G.R., Wallace, D.C. Nat. Genet. (1997) [Pubmed]
  15. Natural history of lactic acidosis after grand-mal seizures. A model for the study of an anion-gap acidosis not associated with hyperkalemia. Orringer, C.E., Eustace, J.C., Wunsch, C.D., Gardner, L.B. N. Engl. J. Med. (1977) [Pubmed]
  16. The acidosis of cholera. Contributions of hyperproteinemia, lactic acidemia, and hyperphosphatemia to an increased serum anion gap. Wang, F., Butler, T., Rabbani, G.H., Jones, P.K. N. Engl. J. Med. (1986) [Pubmed]
  17. Editorial: Aldosterone, potassium and acidosis. Williams, G.H. N. Engl. J. Med. (1976) [Pubmed]
  18. Hyperkalemic distal renal tubular acidosis associated with obstructive uropathy. Batlle, D.C., Arruda, J.A., Kurtzman, N.A. N. Engl. J. Med. (1981) [Pubmed]
  19. Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance. Kaila, K., Voipio, J. Nature (1987) [Pubmed]
  20. Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis. Laghmani, K., Preisig, P.A., Moe, O.W., Yanagisawa, M., Alpern, R.J. J. Clin. Invest. (2001) [Pubmed]
  21. Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53. Webster, K.A., Discher, D.J., Kaiser, S., Hernandez, O., Sato, B., Bishopric, N.H. J. Clin. Invest. (1999) [Pubmed]
  22. Spironolactone-induced hyperchloremic acidosis in cirrhosis. Gabow, P.A., Moore, S., Schrier, R.W. Ann. Intern. Med. (1979) [Pubmed]
  23. Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Kubasiak, L.A., Hernandez, O.M., Bishopric, N.H., Webster, K.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  24. A phosphorus-31 nuclear magnetic resonance study of the metabolic, contractile, and ionic consequences of induced calcium alterations in the isovolumic rat heart. Hoerter, J.A., Miceli, M.V., Renlund, D.G., Jacobus, W.E., Gerstenblith, G., Lakatta, E.G. Circ. Res. (1986) [Pubmed]
  25. Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. Ugawa, S., Ueda, T., Ishida, Y., Nishigaki, M., Shibata, Y., Shimada, S. J. Clin. Invest. (2002) [Pubmed]
  26. The relative importance of HCO3- and blood flow in the protection of rat gastric mucosa during shock. Starlinger, M., Jakesz, R., Matthews, J.B., Yoon, C., Schiessel, R. Gastroenterology (1981) [Pubmed]
  27. Effect of hypercapnic acidemia on anisotropic propagation in the canine ventricle. Vorperian, V.R., Wisialowski, T.A., Deegan, R., Roden, D.M. Circulation (1994) [Pubmed]
  28. Endothelin reverses the effects of acidosis on the intracellular Ca2+ transient and contractility in ferret myocardium. Wang, J., Morgan, J.P. Circ. Res. (1992) [Pubmed]
  29. Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Gao, J., Duan, B., Wang, D.G., Deng, X.H., Zhang, G.Y., Xu, L., Xu, T.L. Neuron (2005) [Pubmed]
  30. The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Finberg, K.E., Wagner, C.A., Bailey, M.A., Paunescu, T.G., Breton, S., Brown, D., Giebisch, G., Geibel, J.P., Lifton, R.P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Wilson, F.H., Kahle, K.T., Sabath, E., Lalioti, M.D., Rapson, A.K., Hoover, R.S., Hebert, S.C., Gamba, G., Lifton, R.P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  32. Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. Babinski, K., Catarsi, S., Biagini, G., Séguéla, P. J. Biol. Chem. (2000) [Pubmed]
  33. A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. Dinour, D., Chang, M.H., Satoh, J., Smith, B.L., Angle, N., Knecht, A., Serban, I., Holtzman, E.J., Romero, M.F. J. Biol. Chem. (2004) [Pubmed]
  34. Contribution of individual superficial nephron segments to ammonium handling in chronic metabolic acidosis in the rat. Evidence for ammonia disequilibrium in the renal cortex. Simon, E., Martin, D., Buerkert, J. J. Clin. Invest. (1985) [Pubmed]
  35. Amelioration of hypoglycemia in a patient with malignant insulinoma during the development of the ectopic ACTH syndrome. Sadoff, L., Gordon, J., Goldman, S. Diabetes (1975) [Pubmed]
  36. Hemodialysis for methanol intoxication. Gonda, A., Gault, H., Churchill, D., Hollomby, D. Am. J. Med. (1978) [Pubmed]
  37. Oral rehydration therapy: efficacy of sodium citrate equals to sodium bicarbonate for correction of acidosis in diarrhoea. Islam, M.R., Samadi, A.R., Ahmed, S.M., Bardhan, P.K., Ali, A. Gut (1984) [Pubmed]
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