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Gene Review:

IL12RB2 - interleukin 12 receptor, beta 2

Sus scrofa

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High impact information on IL12RB2

Porcine IL-12Rbeta2 gene was cloned from mRNA preparation of mitogen-activated peripheral blood mononuclear cells (PBMCs), and its complete nucleotide sequence was determined [1].
Limited effect of recombinant porcine interleukin-12 on porcine lymphocytes due to a low level of IL-12 beta2 receptor [2].

Analytical, diagnostic and therapeutic context of IL12RB2

Cloning of porcine interleukin (IL)-12 receptor beta2 (IL-12Rbeta2) gene and its application to a rapid biological assay for human/porcine IL-12 [1].
Real time PCR analysis demonstrated that after PBMC stimulation, bovine blasts had an 11-fold increase in IL-12Rbeta2 mRNA levels while porcine blasts had almost no change [2].

References

Cloning of porcine interleukin (IL)-12 receptor beta2 (IL-12Rbeta2) gene and its application to a rapid biological assay for human/porcine IL-12. Kokuho, T., Inumaru, S., Watanabe, S., Kubota, T. Vet. Immunol. Immunopathol. (2003) [Pubmed]
Limited effect of recombinant porcine interleukin-12 on porcine lymphocytes due to a low level of IL-12 beta2 receptor. Solano-Aguilar, G.I., Zarlenga, D., Beshah, E., Vengroski, K., Gasbarre, L., Junker, D., Cochran, M., Weston, C., Valencia, D., Chiang, C., Dawson, H., Urban, J.F., Lunney, J.K. Vet. Immunol. Immunopathol. (2002) [Pubmed]

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