Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

smc4 - structural maintenance of chromosomes 4

Xenopus laevis

Synonyms: SMC-4, hCAP-C, xcap-c, xsmc4

Hirano, T. et al., Cabello, O.A. et al., Hirano, T. et al.

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High impact information on XCAP-C

Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein [1].
Further, a potential requirement for condensin in completion of chromatid arm separation in early anaphase is demonstrated by the mutational phenotypes of the Drosophila homologues of XCAP-H, barren and XCAP-C, DmSMC4 [2].

Biological context of XCAP-C

Antibody blocking experiments showed that XCAP-C function is required for both assembly and structural maintenance of mitotic chromosomes in vitro [3].

Other interactions of XCAP-C

The 8S form is a heterodimer of XCAP-C and XCAP-E, whereas the 13S form contains three additional subunits [1].

References

Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein. Hirano, T., Kobayashi, R., Hirano, M. Cell (1997) [Pubmed]
Cell cycle-dependent expression and nucleolar localization of hCAP-H. Cabello, O.A., Eliseeva, E., He, W.G., Youssoufian, H., Plon, S.E., Brinkley, B.R., Belmont, J.W. Mol. Biol. Cell (2001) [Pubmed]
A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro. Hirano, T., Mitchison, T.J. Cell (1994) [Pubmed]

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