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Gene Review:

wee2 - WEE1 homolog 2

Xenopus laevis

Synonyms: Xe-wee1, wee1, wee1-b, wee1a, wee1b, ...

Matsuba, C. et al., Okamoto, K. et al., Mueller, P.R. et al.

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High impact information on LOC398017

In Xenopus, the conventional Wee1 homolog (termed Xe-Wee1A, or Wee1A for short) is maternally expressed and functions in pregastrula embryos with rapid cell cycles [1].
During interphase, the activity of this Wee1 homolog does not vary in response to the presence of unreplicated DNA [2].
Wee1 is one of the genes which regulates the cell cycle. cDNA encoding a Wee1-homolog has been isolated from Japanese silver crucian carp (ginbuna) by using polymerase chain reaction (PCR) techniques [3].

References

The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle. Okamoto, K., Nakajo, N., Sagata, N. EMBO J. (2002) [Pubmed]
Cell cycle regulation of a Xenopus Wee1-like kinase. Mueller, P.R., Coleman, T.R., Dunphy, W.G. Mol. Biol. Cell (1995) [Pubmed]
Cloning and sequencing of Wee1 from the ovary of the gynogenetic Japanese silver crucian carp (ginbuna) [Carassius auratus langsdorfi]. Matsuba, C., Murakami, M., Fujitani, H. DNA Seq. (2002) [Pubmed]

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