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Gene Review:

chek2 - checkpoint kinase 2

Xenopus laevis

Gotoh, T. et al., Hutchins, J.R. et al., Wroble, B.N. et al.

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High impact information on Cds1

In vertebrates, Cdc25C is inhibited by phosphorylation at a single site targeted by the checkpoint kinases Chk1 and Cds1/Chk2 in response to DNA damage or replication arrest [1].
Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G(2)/M-phase transition in Xenopus oocytes [2].
Thus, the present study is the first indication of Cds1 activity in cells that are physiologically arrested at G(2)-phase, and of its downregulation at entry into M-phase [2].
Chk2/Cds1 protein kinase blocks apoptosis during early development of Xenopus laevis [3].

Biological context of Cds1

The DNA damage checkpoint is mediated by the Chk2/Cds1 kinase [3].
Chk1 and Cds1/Chk2 are effector kinases in the G(2)-phase checkpoint activated by damaged or unreplicated DNA, and they prevent entry into M-phase through inhibition of cyclin B-Cdc2 kinase activation [2].

References

Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II. Hutchins, J.R., Dikovskaya, D., Clarke, P.R. Mol. Biol. Cell (2003) [Pubmed]
Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G(2)/M-phase transition in Xenopus oocytes. Gotoh, T., Ohsumi, K., Matsui, T., Takisawa, H., Kishimoto, T. J. Cell. Sci. (2001) [Pubmed]
Chk2/Cds1 protein kinase blocks apoptosis during early development of Xenopus laevis. Wroble, B.N., Sible, J.C. Dev. Dyn. (2005) [Pubmed]

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