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Gene Review

mbf1  -  multiprotein bridging factor 1

Drosophila melanogaster

Synonyms: BcDNA:GH10148, BcDNA:GM01267, CG4143, Dmel\CG4143, MBF-1, ...
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High impact information on mbf1

  • We conclude that by preserving the redox-sensitive AP-1 activity, MBF1 provides an advantage during oxidative stress [1].
  • Via a direct interaction with the basic region of Drosophila Jun (D-Jun), MBF1 prevents an oxidative modification (S-cystenyl cystenylation) of the critical cysteine and stimulates AP-1 binding to DNA [1].


  1. Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila. Jindra, M., Gaziova, I., Uhlirova, M., Okabe, M., Hiromi, Y., Hirose, S. EMBO J. (2004) [Pubmed]
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