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Gene Review:

pkp4 - plakophilin 4

Xenopus laevis

Fang, X. et al., Ciesiolka, M. et al.

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Disease relevance of LOC398489

Using an animal model system and depletion-rescue strategies, we have addressed the requirement and functions of armadillo repeat gene deleted in velo-cardio-facial syndrome (ARVCF) and p120 catenins in early vertebrate embryogenesis [1].

High impact information on LOC398489

Closer inspection showed that p120 depletion impaired evagination of the optic vesicles and migration of cranial neural crest cells from the neural tube into the branchial arches [2].

References

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac. Fang, X., Ji, H., Kim, S.W., Park, J.I., Vaught, T.G., Anastasiadis, P.Z., Ciesiolka, M., McCrea, P.D. J. Cell Biol. (2004) [Pubmed]
p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus. Ciesiolka, M., Delvaeye, M., Van Imschoot, G., Verschuere, V., McCrea, P., van Roy, F., Vleminckx, K. J. Cell. Sci. (2004) [Pubmed]

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