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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

gtf2a1l  -  general transcription factor IIA, 1-like

Xenopus laevis

 
 
 
 
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High impact information on ALF

  • When oocytes undergo progesterone-induced maturation, ALF activity disappears, and TFIIA activity is restored [1].
  • ALF is present in both testis and ovary in this organism, and it completely replaces TFIIA in immature oocytes [1].
  • The effects of ALF overexpression and ALF immunodepletion on a thymidine kinase promoter construct demonstrate that this factor serves as an active replacement for TFIIA [1].
  • Overall, the results show that the translationally regulated reciprocal expression of ALF and TFIIA allows for the production of an active TFIIA-like general transcription factor throughout oogenesis [1].

References

  1. Expression of the germ cell-specific transcription factor ALF in Xenopus oocytes compensates for translational inactivation of the somatic factor TFIIA. Han, S., Xie, W., Hammes, S.R., DeJong, J. J. Biol. Chem. (2003) [Pubmed]
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