Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

argR - arginine repressor ArgR

Escherichia coli UTI89

Merlo, L.M. et al., Samalíková, M. et al.

Merlo, Sadowsky, Ferguson, Dean,

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Disease relevance of argR

In this study we analyzed 537 E. coli strains and show that the argR allele in E. coli B, which causes deregulation, is rare in isolates obtained from natural sources [1].

High impact information on argR

A single nucleotide polymorphism between Escherichia coli strains K12 and B is known to alter the mechanism by which the arginine repressor regulates arginine biosynthesis, from a regulated system in E. coli K12 to a deregulated system in E. coli B [1].
The arginine repressor (ArgR) from Escherichia coli regulates genes for L-arginine metabolism and is a required recombination factor for colE1 plasmid replication [2].

Analytical, diagnostic and therapeutic context of argR

Moreover, sequence analysis of 85 strains shows no evidence of selection at the arginine repressor locus [1].

References

The argRB of Escherichia coli is rare in isolates obtained from natural sources. Merlo, L.M., Sadowsky, M.J., Ferguson, J.A., Dean, A.M. Gene (2006) [Pubmed]
Assembly of the hexameric Escherichia coli arginine repressor investigated by nano-electrospray ionization time-of-flight mass spectrometry. Samalíková, M., Carey, J., Grandori, R. Rapid Commun. Mass Spectrom. (2005) [Pubmed]

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