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Gene Review

neuD  -  sialic acid synthase NeuD

Escherichia coli UTI89

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Disease relevance of neuD


High impact information on neuD


Chemical compound and disease context of neuD

  • These data confirm the role of neuD in E. coli sialic acid capsule synthesis and demonstrate that the neu(III)D homologue from GBS shares a similar enzymatic function [2].


  1. Nucleotide sequence and genetic analysis of the neuD and neuB genes in region 2 of the polysialic acid gene cluster of Escherichia coli K1. Annunziato, P.W., Wright, L.F., Vann, W.F., Silver, R.P. J. Bacteriol. (1995) [Pubmed]
  2. NeuD plays a role in the synthesis of sialic acid in Escherichia coli K1. Daines, D.A., Wright, L.F., Chaffin, D.O., Rubens, C.E., Silver, R.P. FEMS Microbiol. Lett. (2000) [Pubmed]
  3. The Group B Streptococcal Sialic Acid O-Acetyltransferase Is Encoded by neuD, a Conserved Component of Bacterial Sialic Acid Biosynthetic Gene Clusters. Lewis, A.L., Hensler, M.E., Varki, A., Nizet, V. J. Biol. Chem. (2006) [Pubmed]
  4. Separate pathways for O acetylation of polymeric and monomeric sialic acids and identification of sialyl O-acetyl esterase in Escherichia coli K1. Steenbergen, S.M., Lee, Y.C., Vann, W.F., Vionnet, J., Wright, L.F., Vimr, E.R. J. Bacteriol. (2006) [Pubmed]
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