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Chemical Compound Review

Bactifor     5-[(3,4,5-trimethoxyphenyl) methyl]pyrimidi...

Synonyms: Antrimox, Bacticel, Proloprim, Septrin, Trimpex, ...
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Disease relevance of Bactrim


Psychiatry related information on Bactrim


High impact information on Bactrim


Chemical compound and disease context of Bactrim


Biological context of Bactrim


Anatomical context of Bactrim

  • Since death caused by diaminopimelic acid deprivation could release recombinant DNA before DNA is degraded because of thymine starvation, it is important to determine the "survival potential" of the released DNA's. Bacterial and plasmid DNA's extracted from bacterial cells are rapidly degraded when added to low dilutions of rat intestinal contents [25].
  • Trimethoprim therapy for urinary tract infection. Long-term prophylaxis in a uremic patient [26].
  • TMP/SMZ failed to eradicate H. influenzae b from the blood in 85% (17/20) or from the cerebrospinal fluid in 95% (19/20) of infected animals [27].
  • Letter: Bacterial culture of jejunal mucosa in childhood caeliac disease [28].
  • Treatment with trimethoprim rarely selected resistant pathogens in the sputum or resistant Enterobacteriacae in the intestine, although the incidence of resistant coagulase-negative staphylococci on the skin increased with both regimens [29].

Associations of Bactrim with other chemical compounds


Gene context of Bactrim


Analytical, diagnostic and therapeutic context of Bactrim


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  24. Macrolide resistance among invasive Streptococcus pneumoniae isolates. Hyde, T.B., Gay, K., Stephens, D.S., Vugia, D.J., Pass, M., Johnson, S., Barrett, N.L., Schaffner, W., Cieslak, P.R., Maupin, P.S., Zell, E.R., Jorgensen, J.H., Facklam, R.R., Whitney, C.G. JAMA (2001) [Pubmed]
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  29. Comparison of trimethoprim alone with trimethoprim sulphamethoxazole in the treatment of respiratory and urinary infections with particular reference to selection of trimethoprim resistance. Lacey, R.W., Lord, V.L., Gunasekera, H.K., Leiberman, P.J., Luxton, D.E. Lancet (1980) [Pubmed]
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  32. Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine. Iyer, J.K., Milhous, W.K., Cortese, J.F., Kublin, J.G., Plowe, C.V. Lancet (2001) [Pubmed]
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