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Gene Review:

endA - endonuclease I

Escherichia coli UTI89

Altermark, B. et al., Yoshinari, S. et al.

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Disease relevance of endA

The endA gene encoding endonuclease I from the psychrophilic and mildly halophilic bacterium Vibrio salmonicida and from the mesophilic brackish water bacterium Vibrio cholerae have been cloned, over-expressed in Escherichia coli, and purified [1].

High impact information on endA

The genome sequence revealed that it possesses two open reading frames (ORFs) that are homologous to endA, a protein responsible for splicing endonuclease activity in archaea [2].

References

Comparative studies of endonuclease I from cold-adapted Vibrio salmonicida and mesophilic Vibrio cholerae. Altermark, B., Niiranen, L., Willassen, N.P., Smalås, A.O., Moe, E. FEBS J. (2007) [Pubmed]
Functional reconstitution of an archaeal splicing endonuclease in vitro. Yoshinari, S., Fujita, S., Masui, R., Kuramitsu, S., Yokobori, S., Kita, K., Watanabe, Y. Nucleic acids symposium series (2004) (2005) [Pubmed]

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