Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

sox3 - SRY (sex determining region Y)-box 3

Xenopus laevis

Synonyms: Sry, Xlsox3, Xtsox3, sox3-a, xSox-B1

Sullivan, S.A. et al., Heeg-Truesdell, E. et al.

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Disease relevance of sox3

Dorsal mRNA injection causes hypertrophy of the neural plate and expansion of early neural genes (sox3 and otx2), but this is not the result of increased proliferation or expanded neural-inducing mesoderm [1].

High impact information on sox3

Unexpectedly, we also found that blocking canonical Wnt signals in the ectoderm, using the inhibitory XTcf3 mutant or by other means, dramatically expanded the size of the neural plate, as evidenced by the increased expression of early pan-neural markers such as Sox3 and Nrp1 [2].

References

foxD5a, a Xenopus winged helix gene, maintains an immature neural ectoderm via transcriptional repression that is dependent on the C-terminal domain. Sullivan, S.A., Akers, L., Moody, S.A. Dev. Biol. (2001) [Pubmed]
Neural induction in Xenopus requires inhibition of Wnt-beta-catenin signaling. Heeg-Truesdell, E., Labonne, C. Dev. Biol. (2006) [Pubmed]

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