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Gene Review:

bmp3 - bone morphogenetic protein 3

Xenopus laevis

Hino, J. et al., Gamer, L.W. et al., Hino, J. et al.

Gamer, Nove, Levin, Rosen,

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High impact information on xBMP-3

Our results identify BMP-3 as a novel antagonist of both activin and BMPs and uncover how some of the diverse developmental processes that are regulated by both activin and BMP signaling can be modulated during embryogenesis [1].
XBMP-3b is expressed in the prechordal plate, while xBMP-3 is expressed in the notochord [2].
Less BMP-3b than BMP-3 precursor is proteolytically processed in embryos [2].
These findings suggest that the processing of precursor regions and assembly of BMP-3 and 3b are important in various developmental processes and organogenesis [3].
In osteoblasts, BMP-3 and 3b have similar antagonistic activity against BMP-2, but they are differentially regulated [3].

References

BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos. Gamer, L.W., Nove, J., Levin, M., Rosen, V. Dev. Biol. (2005) [Pubmed]
Coordination of BMP-3b and cerberus is required for head formation of Xenopus embryos. Hino, J., Nishimatsu, S., Nagai, T., Matsuo, H., Kangawa, K., Nohno, T. Dev. Biol. (2003) [Pubmed]
Bone morphogenetic protein-3 family members and their biological functions. Hino, J., Kangawa, K., Matsuo, H., Nohno, T., Nishimatsu, S. Front. Biosci. (2004) [Pubmed]

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