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Gene Review: 

Adgf-A  -  Adenosine deaminase-related growth factor A

Drosophila melanogaster

Synonyms: ADGDF-A, ADGF-A, Adgf-a, CG5992, Dmel\CG5992, ...
 
 
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High impact information on Adgf-A

  • The two most abundantly expressed ADGFs in Drosophila larvae are ADGF-A, which is strongly expressed in the gut and lymph glands, and ADGF-D, which is mainly expressed in the fat body and brain [1].
  • The elevated level of adenosine in the hemolymph due to lack of ADGF-A leads to apparently inconsistent phenotypic effects: precocious metamorphic changes including differentiation of macrophage-like cells and fat body disintegration on one hand, and delay of development with block of pupariation on the other [2].

References

  1. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine. Zurovec, M., Dolezal, T., Gazi, M., Pavlova, E., Bryant, P.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. A role for adenosine deaminase in Drosophila larval development. Dolezal, T., Dolezelova, E., Zurovec, M., Bryant, P.J. PLoS Biol. (2005) [Pubmed]
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