Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

skl - sickle

Drosophila melanogaster

Synonyms: BcDNA:RE14076, CG13701, Dmel\CG13701, Skl, meph, ...

Srinivasula, S.M. et al., Christich, A. et al., Clavería, C. et al.

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High impact information on skl

A GH3 homology region is present in the Drosophila proapoptotic proteins Reaper and Sickle [1].
Skl interacts with Drosophila and mammalian IAPs and can promote caspase activation in the presence of IAPs [2].
Skl can also synergize with Grim to induce cell death in the Drosophila eye imaginal disc [2].
Here we describe the functional characterization of the novel Drosophila cell death protein Sickle (Skl), which binds to IAPs and neutralizes their apoptotic inhibitory activity [2].
Consistent with these findings, expression of Skl in Drosophila and mammalian cell lines or in Drosophila embryos induces apoptosis [2].

Other interactions of skl

Like other activators of apoptosis mapping in the Reaper region, full-length skl induced apoptosis when overexpressed, and the N terminus of this protein specifically bound to the BIR2 domain of DIAP1 [3].

References

GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway. Clavería, C., Caminero, E., Martínez-A, C., Campuzano, S., Torres, M. EMBO J. (2002) [Pubmed]
sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. Srinivasula, S.M., Datta, P., Kobayashi, M., Wu, J.W., Fujioka, M., Hegde, R., Zhang, Z., Mukattash, R., Fernandes-Alnemri, T., Shi, Y., Jaynes, J.B., Alnemri, E.S. Curr. Biol. (2002) [Pubmed]
The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Christich, A., Kauppila, S., Chen, P., Sogame, N., Ho, S.I., Abrams, J.M. Curr. Biol. (2002) [Pubmed]

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