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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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About

Terms

 

Gene Review: 

VMAC  -  vimentin-type intermediate filament...

Homo sapiens

Synonyms: Vimentin-type intermediate filament-associated coiled-coil protein
 
 
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Disease relevance of VMAC

 

High impact information on VMAC

  • In VMAC, significantly more adverse events occurred with nitroglycerin than with nesiritide [2].
  • Studies in a recombinant yeast expression system showed that the Leu359 variant had the highest Km and the lowest Vmac for hydroxylation of tolbutamide of all the CYP2C9 allelic variants [3].

References

  1. Nesiritide in perspective: evolving approaches to the management of acute decompensated heart failure. Mills, R.M., Hobbs, R.E. Drugs of today (Barcelona, Spain : 1998) (2003) [Pubmed]
  2. Nesiritide: a review of its use in acute decompensated heart failure. Keating, G.M., Goa, K.L. Drugs (2003) [Pubmed]
  3. The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Sullivan-Klose, T.H., Ghanayem, B.I., Bell, D.A., Zhang, Z.Y., Kaminsky, L.S., Shenfield, G.M., Miners, J.O., Birkett, D.J., Goldstein, J.A. Pharmacogenetics (1996) [Pubmed]
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