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Gene Review:

Acp76A - Accessory gland protein 76A

Drosophila melanogaster

Synonyms: Accessory gland protein Acp76A, Acp76, CG3801, Dmel\CG3801, Spn76A

Wolfner, M.F. et al., Coleman, S. et al.

Wolfner, Harada, Bertram, Stelick, Kraus, Kalb, Lung, Neubaum, Park, Tram,

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Disease relevance of Acp76A

Models are discussed in which Acp76A plays a role in the observed regulation of Acp proteolysis and/or in the coagulation of seminal fluid to form a mating plug, and in which Acp62F contributes to the reported toxicity of Drosophila seminal fluid [1].

High impact information on Acp76A

Acp76A is a 388 amino acid pro-protein which contains a signature sequence for the serpin class of protease inhibitors [1].
Immediately after mating the Acp76A is found in the female uterus [2].

References

New genes for male accessory gland proteins in Drosophila melanogaster. Wolfner, M.F., Harada, H.A., Bertram, M.J., Stelick, T.J., Kraus, K.W., Kalb, J.M., Lung, Y.O., Neubaum, D.M., Park, M., Tram, U. Insect Biochem. Mol. Biol. (1997) [Pubmed]
A Drosophila male accessory gland protein that is a member of the serpin superfamily of proteinase inhibitors is transferred to females during mating. Coleman, S., Drähn, B., Petersen, G., Stolorov, J., Kraus, K. Insect Biochem. Mol. Biol. (1995) [Pubmed]

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