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Gene Review: 

Acp62F  -  Accessory gland protein 62F

Drosophila melanogaster

Synonyms: Accessory gland protein Acp62F, Acp62, Acp62f, CG1262, CT2528, ...
 
 
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Disease relevance of Acp62F

  • A third seminal protein, the protease inhibitor Acp62F, is a candidate for contributing to the survival cost of mating, given its toxicity in ectopic expression assays [1].
 

High impact information on Acp62F

  • Acp62F and Acp70A are also present, although they are located in nonsyntenic regions [2].
  • In light of previous results demonstrating entry of Acp62F into the mated female's hemolymph, we propose that Acp62F is a candidate for a molecule to contribute to the Acp-dependent decrease in female life span [3].
  • We show that in the reproductive tract, Acp62F localizes to the lumen of the uterus and the female's sperm storage organs [3].
  • To address where and how seminal fluid proteins enter the hemolymph of the mated female, we compared the kinetics of transfer and localization in mated females of two seminal fluid proteins that enter the hemolymph (Acp26Aa and Acp62F) and one that does not (Acp36DE) [4].
  • Models are discussed in which Acp76A plays a role in the observed regulation of Acp proteolysis and/or in the coagulation of seminal fluid to form a mating plug, and in which Acp62F contributes to the reported toxicity of Drosophila seminal fluid [5].

References

  1. The gifts that keep on giving: physiological functions and evolutionary dynamics of male seminal proteins in Drosophila. Wolfner, M.F. Heredity (2002) [Pubmed]
  2. Comparative genomics of accessory gland protein genes in Drosophila melanogaster and D. pseudoobscura. Wagstaff, B.J., Begun, D.J. Mol. Biol. Evol. (2005) [Pubmed]
  3. The Drosophila melanogaster seminal fluid protein Acp62F is a protease inhibitor that is toxic upon ectopic expression. Lung, O., Tram, U., Finnerty, C.M., Eipper-Mains, M.A., Kalb, J.M., Wolfner, M.F. Genetics (2002) [Pubmed]
  4. Drosophila seminal fluid proteins enter the circulatory system of the mated female fly by crossing the posterior vaginal wall. Lung, O., Wolfner, M.F. Insect Biochem. Mol. Biol. (1999) [Pubmed]
  5. New genes for male accessory gland proteins in Drosophila melanogaster. Wolfner, M.F., Harada, H.A., Bertram, M.J., Stelick, T.J., Kraus, K.W., Kalb, J.M., Lung, Y.O., Neubaum, D.M., Park, M., Tram, U. Insect Biochem. Mol. Biol. (1997) [Pubmed]
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