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Gene Review

L1RE2  -  LINE1 retrotransposable element 2

Homo sapiens

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High impact information on LRE2

  • We previously isolated two human L1 elements (L1.2 and LRE2) as the progenitors of disease-producing insertions [1].
  • A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion [2].
  • LRE2 has a perfect 13-15 bp target site duplication, two open reading frames, and an unusual 21 bp truncation of the 5' end, suggesting that a slightly truncated element can still retrotranspose [2].
  • There is an L1 element at LRE2 on approximately 66% of human chromosomes 1q, and the element is absent from chimpanzee and gorilla genomes [2].
  • By 5'-deletional analysis and heterologous promoter experiments, two positive-acting LRE were identified between -250 and -200 (LRE3) and -200 and -148 (LRE2) which exhibited cooperativity in that neither element alone was active [3].


  1. High frequency retrotransposition in cultured mammalian cells. Moran, J.V., Holmes, S.E., Naas, T.P., DeBerardinis, R.J., Boeke, J.D., Kazazian, H.H. Cell (1996) [Pubmed]
  2. A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion. Holmes, S.E., Dombroski, B.A., Krebs, C.M., Boehm, C.D., Kazazian, H.H. Nat. Genet. (1994) [Pubmed]
  3. LPS-induced expression of the human IL-1 receptor antagonist gene is controlled by multiple interacting promoter elements. Smith, M.F., Eidlen, D., Arend, W.P., Gutierrez-Hartmann, A. J. Immunol. (1994) [Pubmed]
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