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Gene Review

CYP4A24  -  cytochrome P450 4A24

Sus scrofa

Synonyms: CYP4A25, CYPIVA24
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High impact information on CYP4A24

  • The porcine CYP4A21, CYP4A24 and CYP4A25 enzymes, with an overall identity of 94%, have probably evolved from a common ancestral gene, perhaps in conjunction with species-specific habits [1].
  • The deduced amino acid sequences of CYP4A24 and CYP4A25 share extensive sequence identity (97%) [1].
  • The positions of the variable regions between CYP4A24 and CYP4A25, which are confined to beta-sheets 1 and 4, indicate a possible difference in substrate specificity or regioselectivity [1].

Biological context of CYP4A24

  • Comparison with a genomic segment of a pig CYP4A fatty acid hydroxylase gene ( CYP4A24 ) revealed a sequence identity with CYP4A21 that extends beyond the exons, indicating a common origin by gene duplication [2].

Analytical, diagnostic and therapeutic context of CYP4A24


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